miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage
MiR-34 is a tumour suppressor microRNA known to be upregulated by p53 after DNA damage and plays a critical role in cell cycle arrest and apoptosis. Here the authors show the cell maintains an inactive pool of miR-34 which is rapidly activated after damage via ATM-dependent phosphorylation.
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Nature Portfolio
2016
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oai:doaj.org-article:1a9e7f7933464a6e8a6b14db680cf5b92021-12-02T15:35:22ZmiR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage10.1038/ncomms109542041-1723https://doaj.org/article/1a9e7f7933464a6e8a6b14db680cf5b92016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10954https://doaj.org/toc/2041-1723MiR-34 is a tumour suppressor microRNA known to be upregulated by p53 after DNA damage and plays a critical role in cell cycle arrest and apoptosis. Here the authors show the cell maintains an inactive pool of miR-34 which is rapidly activated after damage via ATM-dependent phosphorylation.David W. SalzmanKotoka NakamuraSunitha NallurMichelle T. DookwahChanatip MetheetrairutFrank J. SlackJoanne B. WeidhaasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David W. Salzman Kotoka Nakamura Sunitha Nallur Michelle T. Dookwah Chanatip Metheetrairut Frank J. Slack Joanne B. Weidhaas miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage |
| description |
MiR-34 is a tumour suppressor microRNA known to be upregulated by p53 after DNA damage and plays a critical role in cell cycle arrest and apoptosis. Here the authors show the cell maintains an inactive pool of miR-34 which is rapidly activated after damage via ATM-dependent phosphorylation. |
| format |
article |
| author |
David W. Salzman Kotoka Nakamura Sunitha Nallur Michelle T. Dookwah Chanatip Metheetrairut Frank J. Slack Joanne B. Weidhaas |
| author_facet |
David W. Salzman Kotoka Nakamura Sunitha Nallur Michelle T. Dookwah Chanatip Metheetrairut Frank J. Slack Joanne B. Weidhaas |
| author_sort |
David W. Salzman |
| title |
miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage |
| title_short |
miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage |
| title_full |
miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage |
| title_fullStr |
miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage |
| title_full_unstemmed |
miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage |
| title_sort |
mir-34 activity is modulated through 5′-end phosphorylation in response to dna damage |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/1a9e7f7933464a6e8a6b14db680cf5b9 |
| work_keys_str_mv |
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| _version_ |
1718386581287469056 |