miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage

miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage

MiR-34 is a tumour suppressor microRNA known to be upregulated by p53 after DNA damage and plays a critical role in cell cycle arrest and apoptosis. Here the authors show the cell maintains an inactive pool of miR-34 which is rapidly activated after damage via ATM-dependent phosphorylation.

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Autores principales: David W. Salzman, Kotoka Nakamura, Sunitha Nallur, Michelle T. Dookwah, Chanatip Metheetrairut, Frank J. Slack, Joanne B. Weidhaas
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/1a9e7f7933464a6e8a6b14db680cf5b9
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