The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside

Henry Michael,1 Thabisile Mpofana,2 Suvira Ramlall,3 Frasia Oosthuizen1 1Discipline of Pharmaceutical Sciences, School of Health Science, University of KwaZulu-Natal, Durban, South Africa; 2School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 3Depart...

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Autores principales:	Michael H, Mpofana T, Ramlall S, Oosthuizen F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	neurotrophins neuroplasticity hiv/aids cognition bdnf Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1aa3d4f3b6834ca88ee0f1d729c9fd82
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spelling	oai:doaj.org-article:1aa3d4f3b6834ca88ee0f1d729c9fd822021-12-02T04:57:23ZThe Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside1178-2021https://doaj.org/article/1aa3d4f3b6834ca88ee0f1d729c9fd822020-01-01T00:00:00Zhttps://www.dovepress.com/the-role-of-brain-derived-neurotrophic-factor-in-hiv-associated-neuroc-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Henry Michael,1 Thabisile Mpofana,2 Suvira Ramlall,3 Frasia Oosthuizen1 1Discipline of Pharmaceutical Sciences, School of Health Science, University of KwaZulu-Natal, Durban, South Africa; 2School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 3Department of Psychiatry, University of KwaZulu-Natal, Durban, South AfricaCorrespondence: Henry MichaelDiscipline of Pharmaceutical Sciences, School of Health Science, University of KwaZulu-Natal, Westville Campus, Durban 4041, South AfricaTel +27 732770601Email doctorprince322@hotmail.comAbstract: Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remains prevalent in the anti-retroviral (ART) era. While there is a complex interplay of many factors in the neuropathogenesis of HAND, decreased neurotrophic synthesis has been shown to contribute to synaptic degeneration which is a hallmark of HAND neuropathology. Brain derived neurotrophic factor (BDNF) is the most abundant and synaptic-promoting neurotrophic factor in the brain and plays a critical role in both learning and memory. Reduced BDNF levels can worsen neurocognitive impairment in HIV-positive individuals across several domains. In this paper, we review the evidence from pre-clinical and clinical studies showing the neuroprotective roles of BDNF against viral proteins, effect on co-morbid mental health disorders, altered human microbiome and ART in HAND management. Potential applications of BDNF modulation in pharmacotherapeutic, cognitive and behavioral interventions in HAND are also discussed. Finally, research gaps and future research direction are identified with the aim of helping researchers to direct efforts to make these BDNF driven interventions improve the quality of life of patients living with HAND.Keywords: neurotrophins, neuroplasticity, HIV/AIDS, cognition, BDNFMichael HMpofana TRamlall SOosthuizen FDove Medical Pressarticleneurotrophinsneuroplasticityhiv/aidscognitionbdnfNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 355-367 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurotrophins neuroplasticity hiv/aids cognition bdnf Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	neurotrophins neuroplasticity hiv/aids cognition bdnf Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Michael H Mpofana T Ramlall S Oosthuizen F The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside
description	Henry Michael,1 Thabisile Mpofana,2 Suvira Ramlall,3 Frasia Oosthuizen1 1Discipline of Pharmaceutical Sciences, School of Health Science, University of KwaZulu-Natal, Durban, South Africa; 2School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 3Department of Psychiatry, University of KwaZulu-Natal, Durban, South AfricaCorrespondence: Henry MichaelDiscipline of Pharmaceutical Sciences, School of Health Science, University of KwaZulu-Natal, Westville Campus, Durban 4041, South AfricaTel +27 732770601Email doctorprince322@hotmail.comAbstract: Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remains prevalent in the anti-retroviral (ART) era. While there is a complex interplay of many factors in the neuropathogenesis of HAND, decreased neurotrophic synthesis has been shown to contribute to synaptic degeneration which is a hallmark of HAND neuropathology. Brain derived neurotrophic factor (BDNF) is the most abundant and synaptic-promoting neurotrophic factor in the brain and plays a critical role in both learning and memory. Reduced BDNF levels can worsen neurocognitive impairment in HIV-positive individuals across several domains. In this paper, we review the evidence from pre-clinical and clinical studies showing the neuroprotective roles of BDNF against viral proteins, effect on co-morbid mental health disorders, altered human microbiome and ART in HAND management. Potential applications of BDNF modulation in pharmacotherapeutic, cognitive and behavioral interventions in HAND are also discussed. Finally, research gaps and future research direction are identified with the aim of helping researchers to direct efforts to make these BDNF driven interventions improve the quality of life of patients living with HAND.Keywords: neurotrophins, neuroplasticity, HIV/AIDS, cognition, BDNF
format	article
author	Michael H Mpofana T Ramlall S Oosthuizen F
author_facet	Michael H Mpofana T Ramlall S Oosthuizen F
author_sort	Michael H
title	The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside
title_short	The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside
title_full	The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside
title_fullStr	The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside
title_full_unstemmed	The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside
title_sort	role of brain derived neurotrophic factor in hiv-associated neurocognitive disorder: from the bench-top to the bedside
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1aa3d4f3b6834ca88ee0f1d729c9fd82
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The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside

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