A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis

Abstract Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer (LC) development; however, there are currently no clinical guidelines for LC surveillance in IPF. This study aimed to investigate the cumulative incidence and survival outcomes of LC in IPF. Using the National...

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Autores principales:	Myung Jin Song, Song Yee Kim, Moo Suk Park, Min Jin Kang, Sang Hoon Lee, Seon Cheol Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1aa4a4a5083643f9a928f2a8cd95f553
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spelling	oai:doaj.org-article:1aa4a4a5083643f9a928f2a8cd95f5532021-12-02T13:57:26ZA nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis10.1038/s41598-021-82182-82045-2322https://doaj.org/article/1aa4a4a5083643f9a928f2a8cd95f5532021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82182-8https://doaj.org/toc/2045-2322Abstract Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer (LC) development; however, there are currently no clinical guidelines for LC surveillance in IPF. This study aimed to investigate the cumulative incidence and survival outcomes of LC in IPF. Using the National Health Insurance Service database, including medical information on people aged ≥ 40 years between 2011 and 2016, we identified IPF patients and confirmed the presence of comorbid LC. Patients diagnosed with IPF in 2011 were washed out, and mortality data were analyzed from 2012 to 2018. A total of 7277 newly diagnosed IPF patients were identified among Korean citizens aged ≥ 40 years (about 50 million people) between 2011 and 2016. Their average age was 71.5 years and 72.8% of them were male. The prevalence of LC in the IPF cases was 6.4%. The cumulative incidence rates of LC in IPF patients who did not have LC at the time of IPF diagnosis were 1.7%, 4.7%, and 7.0%, at 1, 3, and 5 years, respectively. The median time from IPF diagnosis to LC development was 16.3 (Interquartile range, 8.2–28.8) months. The survival rate was significantly lower in the IPF with LC group than the IPF without LC group (P < 0.001). We concluded that IPF increases LC risk, and LC weakens survival outcomes in IPF. Close surveillance for LC development is mandatory for patients with IPF.Myung Jin SongSong Yee KimMoo Suk ParkMin Jin KangSang Hoon LeeSeon Cheol ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Myung Jin Song Song Yee Kim Moo Suk Park Min Jin Kang Sang Hoon Lee Seon Cheol Park A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis
description	Abstract Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer (LC) development; however, there are currently no clinical guidelines for LC surveillance in IPF. This study aimed to investigate the cumulative incidence and survival outcomes of LC in IPF. Using the National Health Insurance Service database, including medical information on people aged ≥ 40 years between 2011 and 2016, we identified IPF patients and confirmed the presence of comorbid LC. Patients diagnosed with IPF in 2011 were washed out, and mortality data were analyzed from 2012 to 2018. A total of 7277 newly diagnosed IPF patients were identified among Korean citizens aged ≥ 40 years (about 50 million people) between 2011 and 2016. Their average age was 71.5 years and 72.8% of them were male. The prevalence of LC in the IPF cases was 6.4%. The cumulative incidence rates of LC in IPF patients who did not have LC at the time of IPF diagnosis were 1.7%, 4.7%, and 7.0%, at 1, 3, and 5 years, respectively. The median time from IPF diagnosis to LC development was 16.3 (Interquartile range, 8.2–28.8) months. The survival rate was significantly lower in the IPF with LC group than the IPF without LC group (P < 0.001). We concluded that IPF increases LC risk, and LC weakens survival outcomes in IPF. Close surveillance for LC development is mandatory for patients with IPF.
format	article
author	Myung Jin Song Song Yee Kim Moo Suk Park Min Jin Kang Sang Hoon Lee Seon Cheol Park
author_facet	Myung Jin Song Song Yee Kim Moo Suk Park Min Jin Kang Sang Hoon Lee Seon Cheol Park
author_sort	Myung Jin Song
title	A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis
title_short	A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis
title_full	A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis
title_fullStr	A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis
title_full_unstemmed	A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis
title_sort	nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1aa4a4a5083643f9a928f2a8cd95f553
work_keys_str_mv	AT myungjinsong anationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT songyeekim anationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT moosukpark anationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT minjinkang anationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT sanghoonlee anationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT seoncheolpark anationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT myungjinsong nationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT songyeekim nationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT moosukpark nationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT minjinkang nationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT sanghoonlee nationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis AT seoncheolpark nationwidepopulationbasedstudyofincidenceandmortalityoflungcancerinidiopathicpulmonaryfibrosis
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A nationwide population-based study of incidence and mortality of lung cancer in idiopathic pulmonary fibrosis

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