Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans

The study of brain clearance mechanisms is an active area of research. While we know that the cerebrospinal fluid (CSF) plays a central role in one of the main existing clearance pathways, the exact processes for the secretion of CSF and the removal of waste products from tissue are under debate. CS...

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Autores principales:	Leonie Petitclerc, Lydiane Hirschler, Jack A. Wells, David L. Thomas, Marianne A.A. van Walderveen, Mark A. van Buchem, Matthias J.P. van Osch
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Arterial spin labeling Blood-csf barrier Neurofluids Glymphatics Brain clearance Water transport Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1aa4f9ffc350416f93765d4156a4833b
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spelling	oai:doaj.org-article:1aa4f9ffc350416f93765d4156a4833b2021-11-30T04:13:42ZUltra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans1095-957210.1016/j.neuroimage.2021.118755https://doaj.org/article/1aa4f9ffc350416f93765d4156a4833b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010272https://doaj.org/toc/1095-9572The study of brain clearance mechanisms is an active area of research. While we know that the cerebrospinal fluid (CSF) plays a central role in one of the main existing clearance pathways, the exact processes for the secretion of CSF and the removal of waste products from tissue are under debate. CSF is thought to be created by the exchange of water and ions from the blood, which is believed to mainly occur in the choroid plexus. This exchange has not been thoroughly studied in vivo.We propose a modified arterial spin labeling (ASL) MRI sequence and image analysis to track blood water as it is transported to the CSF, and to characterize its exchange from blood to CSF. We acquired six pseudo-continuous ASL sequences with varying labeling duration (LD) and post-labeling delay (PLD) and a segmented 3D-GRASE readout with a long echo train (8 echo times (TE)) which allowed separation of the very long-T2 CSF signal. ASL signal was observed at long TEs (793 ms and higher), indicating presence of labeled water transported from blood to CSF. This signal appeared both in the CSF proximal to the choroid plexus and in the subarachnoid space surrounding the cortex. ASL signal was separated into its blood, gray matter and CSF components by fitting a triexponential function with T2s taken from literature. A two-compartment dynamic model was introduced to describe the exchange of water through time and TE. From this, a water exchange time from the blood to the CSF (Tbl->CSF) was mapped, with an order of magnitude of approximately 60 s.Leonie PetitclercLydiane HirschlerJack A. WellsDavid L. ThomasMarianne A.A. van WalderveenMark A. van BuchemMatthias J.P. van OschElsevierarticleArterial spin labelingBlood-csf barrierNeurofluidsGlymphaticsBrain clearanceWater transportNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118755- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arterial spin labeling Blood-csf barrier Neurofluids Glymphatics Brain clearance Water transport Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Arterial spin labeling Blood-csf barrier Neurofluids Glymphatics Brain clearance Water transport Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Leonie Petitclerc Lydiane Hirschler Jack A. Wells David L. Thomas Marianne A.A. van Walderveen Mark A. van Buchem Matthias J.P. van Osch Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans
description	The study of brain clearance mechanisms is an active area of research. While we know that the cerebrospinal fluid (CSF) plays a central role in one of the main existing clearance pathways, the exact processes for the secretion of CSF and the removal of waste products from tissue are under debate. CSF is thought to be created by the exchange of water and ions from the blood, which is believed to mainly occur in the choroid plexus. This exchange has not been thoroughly studied in vivo.We propose a modified arterial spin labeling (ASL) MRI sequence and image analysis to track blood water as it is transported to the CSF, and to characterize its exchange from blood to CSF. We acquired six pseudo-continuous ASL sequences with varying labeling duration (LD) and post-labeling delay (PLD) and a segmented 3D-GRASE readout with a long echo train (8 echo times (TE)) which allowed separation of the very long-T2 CSF signal. ASL signal was observed at long TEs (793 ms and higher), indicating presence of labeled water transported from blood to CSF. This signal appeared both in the CSF proximal to the choroid plexus and in the subarachnoid space surrounding the cortex. ASL signal was separated into its blood, gray matter and CSF components by fitting a triexponential function with T2s taken from literature. A two-compartment dynamic model was introduced to describe the exchange of water through time and TE. From this, a water exchange time from the blood to the CSF (Tbl->CSF) was mapped, with an order of magnitude of approximately 60 s.
format	article
author	Leonie Petitclerc Lydiane Hirschler Jack A. Wells David L. Thomas Marianne A.A. van Walderveen Mark A. van Buchem Matthias J.P. van Osch
author_facet	Leonie Petitclerc Lydiane Hirschler Jack A. Wells David L. Thomas Marianne A.A. van Walderveen Mark A. van Buchem Matthias J.P. van Osch
author_sort	Leonie Petitclerc
title	Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans
title_short	Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans
title_full	Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans
title_fullStr	Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans
title_full_unstemmed	Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans
title_sort	ultra-long-te arterial spin labeling reveals rapid and brain-wide blood-to-csf water transport in humans
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1aa4f9ffc350416f93765d4156a4833b
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Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans

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