Role of prediabetes in stroke

Milija D Mijajlović,1,* Vuk M Aleksić,2,* Nadežda M &Scaron;ternić,1 Mihailo M Mirković,3 Natan M Bornstein4,5 1Neurology Clinic, Clinical Center of Serbia, School of Medicine University of Belgrade, 2Department of Neurosurgery, Clinical Hospital Center Zemun, Belgrade, 3Department of Neurology...

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Autores principales:	Mijajlović MD, Aleksić VM, Šternić NM, Mirković MM, Bornstein NM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Diabetes mellitus Insulin Metabolic syndrome Prediabetes Risk factors Stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1aa6f1169b754383920ac5f4705469ad
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spelling	oai:doaj.org-article:1aa6f1169b754383920ac5f4705469ad2021-12-02T04:18:53ZRole of prediabetes in stroke1178-2021https://doaj.org/article/1aa6f1169b754383920ac5f4705469ad2017-02-01T00:00:00Zhttps://www.dovepress.com/role-of-prediabetes-in-stroke-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Milija D Mijajlović,1,* Vuk M Aleksić,2,* Nadežda M &Scaron;ternić,1 Mihailo M Mirković,3 Natan M Bornstein4,5 1Neurology Clinic, Clinical Center of Serbia, School of Medicine University of Belgrade, 2Department of Neurosurgery, Clinical Hospital Center Zemun, Belgrade, 3Department of Neurology, General Hospital Valjevo, Valjevo, Serbia; 4Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, 5Shaare Zedek Medical Center, Jerusalem, Israel *These authors contributed equally to this work Abstract: Stroke is one of the leading causes of death and probably the greatest cause of adult disability worldwide. Diabetes mellitus (DM) is a state of accelerated aging of blood vessels. Patients with diabetes have increased risk of stroke. Hyperglycemia represents a risk factor for poor outcome following stroke, and probably is just a marker of poor outcome rather than a cause. Lowering of blood glucose levels has not been shown to improve prognosis. Also, prevention of stroke risk among patients with DM is not improved with therapy for reduction of glucose levels. On the other hand, prediabetes, a metabolic state between normal glucose metabolism and diabetes, is a risk factor for the development of DM type 2 and subsequently for stroke. Several methods are known to identify prediabetes patients, including fasting plasma glucose levels, 2-hour post load glucose levels, and glycosylated hemoglobin levels. In this text, we tried to summarize known data about diagnosis, epidemiology, risk factors, pathophysiology, and prevention of prediabetes in relation to DM and stroke. Keywords: diabetes mellitus, insulin, metabolic syndrome, prediabetes, risk factors, strokeMijajlović MDAleksić VMŠternić NMMirković MMBornstein NMDove Medical PressarticleDiabetes mellitusInsulinMetabolic syndromePrediabetesRisk factorsStrokeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 259-267 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetes mellitus Insulin Metabolic syndrome Prediabetes Risk factors Stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Diabetes mellitus Insulin Metabolic syndrome Prediabetes Risk factors Stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mijajlović MD Aleksić VM Šternić NM Mirković MM Bornstein NM Role of prediabetes in stroke
description	Milija D Mijajlović,1,* Vuk M Aleksić,2,* Nadežda M &Scaron;ternić,1 Mihailo M Mirković,3 Natan M Bornstein4,5 1Neurology Clinic, Clinical Center of Serbia, School of Medicine University of Belgrade, 2Department of Neurosurgery, Clinical Hospital Center Zemun, Belgrade, 3Department of Neurology, General Hospital Valjevo, Valjevo, Serbia; 4Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, 5Shaare Zedek Medical Center, Jerusalem, Israel *These authors contributed equally to this work Abstract: Stroke is one of the leading causes of death and probably the greatest cause of adult disability worldwide. Diabetes mellitus (DM) is a state of accelerated aging of blood vessels. Patients with diabetes have increased risk of stroke. Hyperglycemia represents a risk factor for poor outcome following stroke, and probably is just a marker of poor outcome rather than a cause. Lowering of blood glucose levels has not been shown to improve prognosis. Also, prevention of stroke risk among patients with DM is not improved with therapy for reduction of glucose levels. On the other hand, prediabetes, a metabolic state between normal glucose metabolism and diabetes, is a risk factor for the development of DM type 2 and subsequently for stroke. Several methods are known to identify prediabetes patients, including fasting plasma glucose levels, 2-hour post load glucose levels, and glycosylated hemoglobin levels. In this text, we tried to summarize known data about diagnosis, epidemiology, risk factors, pathophysiology, and prevention of prediabetes in relation to DM and stroke. Keywords: diabetes mellitus, insulin, metabolic syndrome, prediabetes, risk factors, stroke
format	article
author	Mijajlović MD Aleksić VM Šternić NM Mirković MM Bornstein NM
author_facet	Mijajlović MD Aleksić VM Šternić NM Mirković MM Bornstein NM
author_sort	Mijajlović MD
title	Role of prediabetes in stroke
title_short	Role of prediabetes in stroke
title_full	Role of prediabetes in stroke
title_fullStr	Role of prediabetes in stroke
title_full_unstemmed	Role of prediabetes in stroke
title_sort	role of prediabetes in stroke
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1aa6f1169b754383920ac5f4705469ad
work_keys_str_mv	AT mijajlovicmd roleofprediabetesinstroke AT aleksicvm roleofprediabetesinstroke AT sternicnm roleofprediabetesinstroke AT mirkovicmm roleofprediabetesinstroke AT bornsteinnm roleofprediabetesinstroke
_version_	1718401295985934336

Role of prediabetes in stroke

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