Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets

Abstract In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in...

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Autores principales:	Marieh Pishnamazi, Hamid Hafizi, Mahboubeh Pishnamazi, Azam Marjani, Saeed Shirazian, Gavin M. Walker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1aa747a171114e06afdef5df79eb0a0a
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spelling	oai:doaj.org-article:1aa747a171114e06afdef5df79eb0a0a2021-12-02T14:01:24ZControlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets10.1038/s41598-020-79983-82045-2322https://doaj.org/article/1aa747a171114e06afdef5df79eb0a0a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79983-8https://doaj.org/toc/2045-2322Abstract In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.Marieh PishnamaziHamid HafiziMahboubeh PishnamaziAzam MarjaniSaeed ShirazianGavin M. WalkerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marieh Pishnamazi Hamid Hafizi Mahboubeh Pishnamazi Azam Marjani Saeed Shirazian Gavin M. Walker Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets
description	Abstract In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.
format	article
author	Marieh Pishnamazi Hamid Hafizi Mahboubeh Pishnamazi Azam Marjani Saeed Shirazian Gavin M. Walker
author_facet	Marieh Pishnamazi Hamid Hafizi Mahboubeh Pishnamazi Azam Marjani Saeed Shirazian Gavin M. Walker
author_sort	Marieh Pishnamazi
title	Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets
title_short	Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets
title_full	Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets
title_fullStr	Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets
title_full_unstemmed	Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets
title_sort	controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica kcc1 compared to microcrystalline cellulose based tablets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1aa747a171114e06afdef5df79eb0a0a
work_keys_str_mv	AT mariehpishnamazi controlledreleaseevaluationofparacetamolloadedaminefunctionalizedmesoporoussilicakcc1comparedtomicrocrystallinecellulosebasedtablets AT hamidhafizi controlledreleaseevaluationofparacetamolloadedaminefunctionalizedmesoporoussilicakcc1comparedtomicrocrystallinecellulosebasedtablets AT mahboubehpishnamazi controlledreleaseevaluationofparacetamolloadedaminefunctionalizedmesoporoussilicakcc1comparedtomicrocrystallinecellulosebasedtablets AT azammarjani controlledreleaseevaluationofparacetamolloadedaminefunctionalizedmesoporoussilicakcc1comparedtomicrocrystallinecellulosebasedtablets AT saeedshirazian controlledreleaseevaluationofparacetamolloadedaminefunctionalizedmesoporoussilicakcc1comparedtomicrocrystallinecellulosebasedtablets AT gavinmwalker controlledreleaseevaluationofparacetamolloadedaminefunctionalizedmesoporoussilicakcc1comparedtomicrocrystallinecellulosebasedtablets
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Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets

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