Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.

Methionine, folic acid, betaine and choline interact in the one-carbon metabolism which provides methyl groups for methylation reactions. An optimal intake of these nutrients during pregnancy is required for successful completion of fetal development and evidence is growing that they could be involv...

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Autores principales:	Fanny Giudicelli, Anne-Laure Brabant, Isabelle Grit, Patricia Parnet, Valérie Amarger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1aaa021fa4714b5f9f43e2b3871fe5f2
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spelling	oai:doaj.org-article:1aaa021fa4714b5f9f43e2b3871fe5f22021-11-18T07:39:14ZExcess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.1932-620310.1371/journal.pone.0068268https://doaj.org/article/1aaa021fa4714b5f9f43e2b3871fe5f22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840890/?tool=EBIhttps://doaj.org/toc/1932-6203Methionine, folic acid, betaine and choline interact in the one-carbon metabolism which provides methyl groups for methylation reactions. An optimal intake of these nutrients during pregnancy is required for successful completion of fetal development and evidence is growing that they could be involved in metabolic long-term programming. However, the biological pathways involved in the action of these nutrients are still poorly known. This study investigated the interaction between methyl donors and protein content in maternal diet during the preconceptual, pregnancy and lactation periods and the consequences on the rat offspring in the short and long term. Methyl donor supplementation reduced leptin secretion in offspring, whereas insulin levels were mostly affected by protein restriction. The joint effect of protein restriction and methyl donor excess strongly impaired postnatal growth in both gender and long term weight gain in male offspring only, without affecting food intake. In addition, rats born from protein restricted and methyl donor supplemented dams gained less weight when fed a hypercaloric diet. Methylation of the leptin gene promoter in adipose tissue was increased in methyl donor supplemented groups but not affected by protein restriction only. These results suggest that maternal methyl donor supplementation may influence energy homeostasis in a gender-dependent manner, without affecting food intake. Moreover, we showed that macronutrients and micronutrients in maternal diet interact to influence the programming of the offspring.Fanny GiudicelliAnne-Laure BrabantIsabelle GritPatricia ParnetValérie AmargerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68268 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fanny Giudicelli Anne-Laure Brabant Isabelle Grit Patricia Parnet Valérie Amarger Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.
description	Methionine, folic acid, betaine and choline interact in the one-carbon metabolism which provides methyl groups for methylation reactions. An optimal intake of these nutrients during pregnancy is required for successful completion of fetal development and evidence is growing that they could be involved in metabolic long-term programming. However, the biological pathways involved in the action of these nutrients are still poorly known. This study investigated the interaction between methyl donors and protein content in maternal diet during the preconceptual, pregnancy and lactation periods and the consequences on the rat offspring in the short and long term. Methyl donor supplementation reduced leptin secretion in offspring, whereas insulin levels were mostly affected by protein restriction. The joint effect of protein restriction and methyl donor excess strongly impaired postnatal growth in both gender and long term weight gain in male offspring only, without affecting food intake. In addition, rats born from protein restricted and methyl donor supplemented dams gained less weight when fed a hypercaloric diet. Methylation of the leptin gene promoter in adipose tissue was increased in methyl donor supplemented groups but not affected by protein restriction only. These results suggest that maternal methyl donor supplementation may influence energy homeostasis in a gender-dependent manner, without affecting food intake. Moreover, we showed that macronutrients and micronutrients in maternal diet interact to influence the programming of the offspring.
format	article
author	Fanny Giudicelli Anne-Laure Brabant Isabelle Grit Patricia Parnet Valérie Amarger
author_facet	Fanny Giudicelli Anne-Laure Brabant Isabelle Grit Patricia Parnet Valérie Amarger
author_sort	Fanny Giudicelli
title	Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.
title_short	Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.
title_full	Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.
title_fullStr	Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.
title_full_unstemmed	Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.
title_sort	excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1aaa021fa4714b5f9f43e2b3871fe5f2
work_keys_str_mv	AT fannygiudicelli excessofmethyldonorintheperinatalperiodreducespostnatalleptinsecretioninratandinteractswiththeeffectofproteincontentindiet AT annelaurebrabant excessofmethyldonorintheperinatalperiodreducespostnatalleptinsecretioninratandinteractswiththeeffectofproteincontentindiet AT isabellegrit excessofmethyldonorintheperinatalperiodreducespostnatalleptinsecretioninratandinteractswiththeeffectofproteincontentindiet AT patriciaparnet excessofmethyldonorintheperinatalperiodreducespostnatalleptinsecretioninratandinteractswiththeeffectofproteincontentindiet AT valerieamarger excessofmethyldonorintheperinatalperiodreducespostnatalleptinsecretioninratandinteractswiththeeffectofproteincontentindiet
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Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in diet.

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