Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Production of inflammatory mediators by M1-polarized macrophages is thought to rely on suppression of mitochondrial metabolism in favor of glycolysis. Refining this concept, here the authors define metabolic targets of nitric oxide as responsible for the mitochondrial rewiring resulting from polariz...

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Autores principales:	Erika M. Palmieri, Marieli Gonzalez-Cotto, Walter A. Baseler, Luke C. Davies, Bart Ghesquière, Nunziata Maio, Christopher M. Rice, Tracey A. Rouault, Teresa Cassel, Richard M. Higashi, Andrew N. Lane, Teresa W.-M. Fan, David A. Wink, Daniel W. McVicar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1aabd0cb2c6e480fa1e6ac1eb3b1dd56
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spelling	oai:doaj.org-article:1aabd0cb2c6e480fa1e6ac1eb3b1dd562021-12-02T15:33:50ZNitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase10.1038/s41467-020-14433-72041-1723https://doaj.org/article/1aabd0cb2c6e480fa1e6ac1eb3b1dd562020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14433-7https://doaj.org/toc/2041-1723Production of inflammatory mediators by M1-polarized macrophages is thought to rely on suppression of mitochondrial metabolism in favor of glycolysis. Refining this concept, here the authors define metabolic targets of nitric oxide as responsible for the mitochondrial rewiring resulting from polarization.Erika M. PalmieriMarieli Gonzalez-CottoWalter A. BaselerLuke C. DaviesBart GhesquièreNunziata MaioChristopher M. RiceTracey A. RouaultTeresa CasselRichard M. HigashiAndrew N. LaneTeresa W.-M. FanDavid A. WinkDaniel W. McVicarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erika M. Palmieri Marieli Gonzalez-Cotto Walter A. Baseler Luke C. Davies Bart Ghesquière Nunziata Maio Christopher M. Rice Tracey A. Rouault Teresa Cassel Richard M. Higashi Andrew N. Lane Teresa W.-M. Fan David A. Wink Daniel W. McVicar Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
description	Production of inflammatory mediators by M1-polarized macrophages is thought to rely on suppression of mitochondrial metabolism in favor of glycolysis. Refining this concept, here the authors define metabolic targets of nitric oxide as responsible for the mitochondrial rewiring resulting from polarization.
format	article
author	Erika M. Palmieri Marieli Gonzalez-Cotto Walter A. Baseler Luke C. Davies Bart Ghesquière Nunziata Maio Christopher M. Rice Tracey A. Rouault Teresa Cassel Richard M. Higashi Andrew N. Lane Teresa W.-M. Fan David A. Wink Daniel W. McVicar
author_facet	Erika M. Palmieri Marieli Gonzalez-Cotto Walter A. Baseler Luke C. Davies Bart Ghesquière Nunziata Maio Christopher M. Rice Tracey A. Rouault Teresa Cassel Richard M. Higashi Andrew N. Lane Teresa W.-M. Fan David A. Wink Daniel W. McVicar
author_sort	Erika M. Palmieri
title	Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
title_short	Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
title_full	Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
title_fullStr	Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
title_full_unstemmed	Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
title_sort	nitric oxide orchestrates metabolic rewiring in m1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1aabd0cb2c6e480fa1e6ac1eb3b1dd56
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Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

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