Is histological remission of ulcerative colitis achievable?

Current conception of deep remission in patients with ulcerative colitis (UC) consists of clinical remission, endoscopic mucosal healing and normalization of laboratory markers. Histological remission should not be used as a primary end point for therapeutic efficacy, but instead should be considere...

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Autores principales:	Oleg V. Knyazev, Anna V. Kagramanova, Sergei G. Khomeriki, Asfold I. Parfenov
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	histological index histological remission ulcerative colitis Medicine R
Acceso en línea:	https://doaj.org/article/1aac92c3c4464e48b4b5acc361e254e9
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spelling	oai:doaj.org-article:1aac92c3c4464e48b4b5acc361e254e92021-12-01T12:22:36ZIs histological remission of ulcerative colitis achievable?0040-36602309-534210.26442/00403660.2021.08.200981https://doaj.org/article/1aac92c3c4464e48b4b5acc361e254e92021-08-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/79596/60212https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342Current conception of deep remission in patients with ulcerative colitis (UC) consists of clinical remission, endoscopic mucosal healing and normalization of laboratory markers. Histological remission should not be used as a primary end point for therapeutic efficacy, but instead should be considered as a marker of deep remission. The main goal of UC treatment should be focused on endoscopic healing of colon mucosa, decrease of inflammation activity, prolonged remission, absence of disease recurrence, and also histologic remission. Nevertheless, the term histologic remission has not yet been fully validated and no histologic indexes have been standardized. We need single unified definition for remission, based on multicentral studies analysis. One of important challenge is restoration of normal colon mucosal and results of multiple studies showed contradictory tests for assessing histologic remission, thus remaining an issue for further discussion.Oleg V. KnyazevAnna V. KagramanovaSergei G. KhomerikiAsfold I. Parfenov"Consilium Medicum" Publishing housearticlehistological indexhistological remissionulcerative colitisMedicineRRUТерапевтический архив, Vol 93, Iss 8, Pp 975-981 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	histological index histological remission ulcerative colitis Medicine R
spellingShingle	histological index histological remission ulcerative colitis Medicine R Oleg V. Knyazev Anna V. Kagramanova Sergei G. Khomeriki Asfold I. Parfenov Is histological remission of ulcerative colitis achievable?
description	Current conception of deep remission in patients with ulcerative colitis (UC) consists of clinical remission, endoscopic mucosal healing and normalization of laboratory markers. Histological remission should not be used as a primary end point for therapeutic efficacy, but instead should be considered as a marker of deep remission. The main goal of UC treatment should be focused on endoscopic healing of colon mucosa, decrease of inflammation activity, prolonged remission, absence of disease recurrence, and also histologic remission. Nevertheless, the term histologic remission has not yet been fully validated and no histologic indexes have been standardized. We need single unified definition for remission, based on multicentral studies analysis. One of important challenge is restoration of normal colon mucosal and results of multiple studies showed contradictory tests for assessing histologic remission, thus remaining an issue for further discussion.
format	article
author	Oleg V. Knyazev Anna V. Kagramanova Sergei G. Khomeriki Asfold I. Parfenov
author_facet	Oleg V. Knyazev Anna V. Kagramanova Sergei G. Khomeriki Asfold I. Parfenov
author_sort	Oleg V. Knyazev
title	Is histological remission of ulcerative colitis achievable?
title_short	Is histological remission of ulcerative colitis achievable?
title_full	Is histological remission of ulcerative colitis achievable?
title_fullStr	Is histological remission of ulcerative colitis achievable?
title_full_unstemmed	Is histological remission of ulcerative colitis achievable?
title_sort	is histological remission of ulcerative colitis achievable?
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/1aac92c3c4464e48b4b5acc361e254e9
work_keys_str_mv	AT olegvknyazev ishistologicalremissionofulcerativecolitisachievable AT annavkagramanova ishistologicalremissionofulcerativecolitisachievable AT sergeigkhomeriki ishistologicalremissionofulcerativecolitisachievable AT asfoldiparfenov ishistologicalremissionofulcerativecolitisachievable
_version_	1718405162186309632

Is histological remission of ulcerative colitis achievable?

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