Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study

Abebe Muche Belete,1 Taklo Simeneh Yazie2 1Department of Medicine, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Amhara, Ethiopia; 2Pharmacology Unit and Research Team, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Amhara,...

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Autores principales:	Belete AM, Yazie TS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	chronic kidney disease tenofovir disoproxil fumarate human immunodeficiency virus factors ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1aadb60076944fd7bf6eb7ce53ed3cdd
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spelling	oai:doaj.org-article:1aadb60076944fd7bf6eb7ce53ed3cdd2021-12-02T14:13:28ZChronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study1179-1373https://doaj.org/article/1aadb60076944fd7bf6eb7ce53ed3cdd2021-03-01T00:00:00Zhttps://www.dovepress.com/chronic-kidney-disease-and-associated-factors-among-hiv-infected-patie-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Abebe Muche Belete,1 Taklo Simeneh Yazie2 1Department of Medicine, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Amhara, Ethiopia; 2Pharmacology Unit and Research Team, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Amhara, EthiopiaCorrespondence: Taklo Simeneh Yazie Email taklosimeneh23@gmail.comBackground: Life expectancy of HIV patients has increased by the extensive use of antiretroviral therapies (ART), but ART predisposes patients to chronic non-communicable diseases including chronic kidney disease (CKD). Tenofovir disoproxil fumarate is one of the commonly used drugs in ART and is found to have more risk for developing CKD. In the study areas, there was no previous study addressing the prevalence of CKD, so the purpose of this study was to pinpoint the prevalence of CKD, and its associated factors.Methods: A hospital-based cross-sectional study was employed at Tikur Anbessa Specialized Hospital (TASH) and Zewuditu Memorial Hospital (ZMH) from April 1 to June 30, 2019. The study participants were proportionally allocated to each hospital and a total of 243 eligible participants were selected conveniently from the two hospitals in the study period. Structured questionnaire and checklist were used to collect socio-demographic and clinical data of the participants. Blood samples (3– 5 ml) were used to determine serum creatinine using calibrated fully automated Mind ray BS-200E, and glomerular filtration rate (GFR) was estimated using a chronic kidney disease epidemiology equation. Multivariate logistic regression was employed to identify factors associated with CKD, and a P-value of less than 0.05 was considered significant.Results: In the present study, the prevalence of CKD (GFR < 60 ml/min/1.73 m2) was 4.53% (95% CI = 2.3– 8%). GFR was classified into stages, stage 5 (GFR < 15), stage 4 (15– 29.9), stage 3 (30– 59.9), stage 2 (60– 89.9), and stage 1 (≥ 90) were 0%, 0.4%, 4.1%, 38.3%, and 57.2%, respectively. In the multivariate logistic regression, age greater than 50 years old, and having cancer were significantly associated with CKD (AOR: 0.22, 95% CI = 0.05– 0.88, P = 0.033, and AOR: 18.20, 95% CI = 122– 271.77, P = 0.035, respectively).Conclusion: Chronic kidney disease in HIV-infected patients receiving a TDF-based regimen requires attention. Age > 50 years old, and having cancer as comorbidity were significantly associated with chronic kidney disease. Patients should be regularly monitored for early diagnosis and management of chronic kidney disease in a TDF-based regimen.Keywords: chronic kidney disease, tenofovir disoproxil fumarate, human immunodeficiency virus, factors, EthiopiaBelete AMYazie TSDove Medical Pressarticlechronic kidney diseasetenofovir disoproxil fumaratehuman immunodeficiency virusfactorsethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 301-306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease tenofovir disoproxil fumarate human immunodeficiency virus factors ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	chronic kidney disease tenofovir disoproxil fumarate human immunodeficiency virus factors ethiopia Immunologic diseases. Allergy RC581-607 Belete AM Yazie TS Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study
description	Abebe Muche Belete,1 Taklo Simeneh Yazie2 1Department of Medicine, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Amhara, Ethiopia; 2Pharmacology Unit and Research Team, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Amhara, EthiopiaCorrespondence: Taklo Simeneh Yazie Email taklosimeneh23@gmail.comBackground: Life expectancy of HIV patients has increased by the extensive use of antiretroviral therapies (ART), but ART predisposes patients to chronic non-communicable diseases including chronic kidney disease (CKD). Tenofovir disoproxil fumarate is one of the commonly used drugs in ART and is found to have more risk for developing CKD. In the study areas, there was no previous study addressing the prevalence of CKD, so the purpose of this study was to pinpoint the prevalence of CKD, and its associated factors.Methods: A hospital-based cross-sectional study was employed at Tikur Anbessa Specialized Hospital (TASH) and Zewuditu Memorial Hospital (ZMH) from April 1 to June 30, 2019. The study participants were proportionally allocated to each hospital and a total of 243 eligible participants were selected conveniently from the two hospitals in the study period. Structured questionnaire and checklist were used to collect socio-demographic and clinical data of the participants. Blood samples (3– 5 ml) were used to determine serum creatinine using calibrated fully automated Mind ray BS-200E, and glomerular filtration rate (GFR) was estimated using a chronic kidney disease epidemiology equation. Multivariate logistic regression was employed to identify factors associated with CKD, and a P-value of less than 0.05 was considered significant.Results: In the present study, the prevalence of CKD (GFR < 60 ml/min/1.73 m2) was 4.53% (95% CI = 2.3– 8%). GFR was classified into stages, stage 5 (GFR < 15), stage 4 (15– 29.9), stage 3 (30– 59.9), stage 2 (60– 89.9), and stage 1 (≥ 90) were 0%, 0.4%, 4.1%, 38.3%, and 57.2%, respectively. In the multivariate logistic regression, age greater than 50 years old, and having cancer were significantly associated with CKD (AOR: 0.22, 95% CI = 0.05– 0.88, P = 0.033, and AOR: 18.20, 95% CI = 122– 271.77, P = 0.035, respectively).Conclusion: Chronic kidney disease in HIV-infected patients receiving a TDF-based regimen requires attention. Age > 50 years old, and having cancer as comorbidity were significantly associated with chronic kidney disease. Patients should be regularly monitored for early diagnosis and management of chronic kidney disease in a TDF-based regimen.Keywords: chronic kidney disease, tenofovir disoproxil fumarate, human immunodeficiency virus, factors, Ethiopia
format	article
author	Belete AM Yazie TS
author_facet	Belete AM Yazie TS
author_sort	Belete AM
title	Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study
title_short	Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study
title_full	Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study
title_fullStr	Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study
title_full_unstemmed	Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study
title_sort	chronic kidney disease and associated factors among hiv infected patients taking tenofovir disoproxil fumarate based regimen in ethiopia: a hospital-based cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1aadb60076944fd7bf6eb7ce53ed3cdd
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Chronic Kidney Disease and Associated Factors Among HIV Infected Patients Taking Tenofovir Disoproxil Fumarate Based Regimen in Ethiopia: A Hospital-Based Cross-Sectional Study

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