Capicua regulates the development of adult-born neurons in the hippocampus

Abstract New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation. To generate functional adult-born neurons, neural progenitor cells proliferate to expand the precursor cell pool and differentiate into...

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Autores principales:	Brenna Hourigan, Spencer D. Balay, Graydon Yee, Saloni Sharma, Qiumin Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ab0ec949d5a472d82cf3d13eaf78691
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spelling	oai:doaj.org-article:1ab0ec949d5a472d82cf3d13eaf786912021-12-02T15:57:11ZCapicua regulates the development of adult-born neurons in the hippocampus10.1038/s41598-021-91168-52045-2322https://doaj.org/article/1ab0ec949d5a472d82cf3d13eaf786912021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91168-5https://doaj.org/toc/2045-2322Abstract New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation. To generate functional adult-born neurons, neural progenitor cells proliferate to expand the precursor cell pool and differentiate into neurons. Newly generated cells then undergo postmitotic maturation to migrate to their final destination and develop elaborate dendritic branching, which allows them to receive input signals. Little is known about factors that regulate neuronal differentiation, migration, and dendrite maturation during adult hippocampal neurogenesis. Here, we show that the transcriptional repressor protein capicua (CIC) exhibits dynamic expression in the adult dentate gyrus. Conditional deletion of Cic from the mouse dentate gyrus compromises the adult neural progenitor cell pool without altering their proliferative potential. We further demonstrate that the loss of Cic impedes neuronal lineage development and disrupts dendritic arborization and migration of adult-born neurons. Our study uncovers a previously unrecognized role of CIC in neurogenesis of the adult dentate gyrus.Brenna HouriganSpencer D. BalayGraydon YeeSaloni SharmaQiumin TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brenna Hourigan Spencer D. Balay Graydon Yee Saloni Sharma Qiumin Tan Capicua regulates the development of adult-born neurons in the hippocampus
description	Abstract New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation. To generate functional adult-born neurons, neural progenitor cells proliferate to expand the precursor cell pool and differentiate into neurons. Newly generated cells then undergo postmitotic maturation to migrate to their final destination and develop elaborate dendritic branching, which allows them to receive input signals. Little is known about factors that regulate neuronal differentiation, migration, and dendrite maturation during adult hippocampal neurogenesis. Here, we show that the transcriptional repressor protein capicua (CIC) exhibits dynamic expression in the adult dentate gyrus. Conditional deletion of Cic from the mouse dentate gyrus compromises the adult neural progenitor cell pool without altering their proliferative potential. We further demonstrate that the loss of Cic impedes neuronal lineage development and disrupts dendritic arborization and migration of adult-born neurons. Our study uncovers a previously unrecognized role of CIC in neurogenesis of the adult dentate gyrus.
format	article
author	Brenna Hourigan Spencer D. Balay Graydon Yee Saloni Sharma Qiumin Tan
author_facet	Brenna Hourigan Spencer D. Balay Graydon Yee Saloni Sharma Qiumin Tan
author_sort	Brenna Hourigan
title	Capicua regulates the development of adult-born neurons in the hippocampus
title_short	Capicua regulates the development of adult-born neurons in the hippocampus
title_full	Capicua regulates the development of adult-born neurons in the hippocampus
title_fullStr	Capicua regulates the development of adult-born neurons in the hippocampus
title_full_unstemmed	Capicua regulates the development of adult-born neurons in the hippocampus
title_sort	capicua regulates the development of adult-born neurons in the hippocampus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ab0ec949d5a472d82cf3d13eaf78691
work_keys_str_mv	AT brennahourigan capicuaregulatesthedevelopmentofadultbornneuronsinthehippocampus AT spencerdbalay capicuaregulatesthedevelopmentofadultbornneuronsinthehippocampus AT graydonyee capicuaregulatesthedevelopmentofadultbornneuronsinthehippocampus AT salonisharma capicuaregulatesthedevelopmentofadultbornneuronsinthehippocampus AT qiumintan capicuaregulatesthedevelopmentofadultbornneuronsinthehippocampus
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Capicua regulates the development of adult-born neurons in the hippocampus

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