Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Glioblastomas (GBM) are frequently resistant to immune checkpoint blockade therapy. Here the authors show that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.

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Autores principales:	Zohreh Amoozgar, Jonas Kloepper, Jun Ren, Rong En Tay, Samuel W. Kazer, Evgeny Kiner, Shanmugarajan Krishnan, Jessica M. Posada, Mitrajit Ghosh, Emilie Mamessier, Christina Wong, Gino B. Ferraro, Ana Batista, Nancy Wang, Mark Badeaux, Sylvie Roberge, Lei Xu, Peigen Huang, Alex K. Shalek, Dai Fukumura, Hye-Jung Kim, Rakesh K. Jain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ab21691b67f4af6a88731fc02b3c2eb
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spelling	oai:doaj.org-article:1ab21691b67f4af6a88731fc02b3c2eb2021-12-02T14:35:39ZTargeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas10.1038/s41467-021-22885-82041-1723https://doaj.org/article/1ab21691b67f4af6a88731fc02b3c2eb2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22885-8https://doaj.org/toc/2041-1723Glioblastomas (GBM) are frequently resistant to immune checkpoint blockade therapy. Here the authors show that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.Zohreh AmoozgarJonas KloepperJun RenRong En TaySamuel W. KazerEvgeny KinerShanmugarajan KrishnanJessica M. PosadaMitrajit GhoshEmilie MamessierChristina WongGino B. FerraroAna BatistaNancy WangMark BadeauxSylvie RobergeLei XuPeigen HuangAlex K. ShalekDai FukumuraHye-Jung KimRakesh K. JainNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zohreh Amoozgar Jonas Kloepper Jun Ren Rong En Tay Samuel W. Kazer Evgeny Kiner Shanmugarajan Krishnan Jessica M. Posada Mitrajit Ghosh Emilie Mamessier Christina Wong Gino B. Ferraro Ana Batista Nancy Wang Mark Badeaux Sylvie Roberge Lei Xu Peigen Huang Alex K. Shalek Dai Fukumura Hye-Jung Kim Rakesh K. Jain Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
description	Glioblastomas (GBM) are frequently resistant to immune checkpoint blockade therapy. Here the authors show that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.
format	article
author	Zohreh Amoozgar Jonas Kloepper Jun Ren Rong En Tay Samuel W. Kazer Evgeny Kiner Shanmugarajan Krishnan Jessica M. Posada Mitrajit Ghosh Emilie Mamessier Christina Wong Gino B. Ferraro Ana Batista Nancy Wang Mark Badeaux Sylvie Roberge Lei Xu Peigen Huang Alex K. Shalek Dai Fukumura Hye-Jung Kim Rakesh K. Jain
author_facet	Zohreh Amoozgar Jonas Kloepper Jun Ren Rong En Tay Samuel W. Kazer Evgeny Kiner Shanmugarajan Krishnan Jessica M. Posada Mitrajit Ghosh Emilie Mamessier Christina Wong Gino B. Ferraro Ana Batista Nancy Wang Mark Badeaux Sylvie Roberge Lei Xu Peigen Huang Alex K. Shalek Dai Fukumura Hye-Jung Kim Rakesh K. Jain
author_sort	Zohreh Amoozgar
title	Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
title_short	Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
title_full	Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
title_fullStr	Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
title_full_unstemmed	Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
title_sort	targeting treg cells with gitr activation alleviates resistance to immunotherapy in murine glioblastomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ab21691b67f4af6a88731fc02b3c2eb
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Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

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