Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.

<h4>Background</h4>Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV.<h4>Methods</...

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Autores principales:	Kim A Nguyen, Nasheeta Peer, Andre P Kengne
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ab4246431b9499fb2fc19381af9b259
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spelling	oai:doaj.org-article:1ab4246431b9499fb2fc19381af9b2592021-12-02T20:05:44ZAssociations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.1932-620310.1371/journal.pone.0246131https://doaj.org/article/1ab4246431b9499fb2fc19381af9b2592021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0246131https://doaj.org/toc/1932-6203<h4>Background</h4>Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV.<h4>Methods</h4>In this cross-sectional study, HIV-infected adults were randomly recruited across 17 HIV clinics in the Western Cape Province. Homeostatic model assessment for insulin resistance (HOMA-IR), hypertension, diabetes, metabolic syndrome by Joint Interim Statement criteria (JIS-MS), a ≥5% and ≥10% predicted risk for a CVD event within 10 years by the Framingham risk score (10-years-CVD risk) were computed. Associations between GGT and cardio-metabolic trait were explored using linear and binomial logistic regressions adjusted for age, gender, lifestyle behaviours and HIV-related characteristics.<h4>Results</h4>Among 709 participants (561 women, mean age 38.6 years), log-GGT was positively associated with waist circumference (β=2.75; p<0.001), diastolic blood pressure (β=1.65; p=0.006), total cholesterol (β=0.21; p<0.001), low-density lipoprotein-cholesterol (β=0.16; p<0.001), high-density lipoprotein-cholesterol and log-triglycerides (both β=0.12; p<0.001), fasting plasma glucose (β=0.19; p=0.031), 2-hour-post-glucose-load plasma glucose (β=0.26; p=0.007), HOMA-IR (β=0.13; p=0.001), log-high-sensitivity C-reactive-protein (β=0.3; p<0.001) in linear regression analyses; with hypertension [OR=1.41 (95%CI, 1.13-1.75); p=0.001], JIS-MS [OR=1.33 (1.05-1.68); p=0.016], ≥5% 10-year-CVD risk [OR=1.55 (1.24-1.9400); p<0.001] and ≥10% 10-year-CVD risk [OR=1.56 (1.08-2.23); p=0.016] but not with diabetes [OR=1.24 (0.88-1.71), p=0.205] in logistic regression analyses.<h4>Conclusions</h4>In this study, GGT levels were associated with cardio-metabolic variables independent of HIV specific attributes. If confirmed in longitudinal studies, GGT evaluation maybe included in CVD risk monitoring strategies in people living with HIV.Kim A NguyenNasheeta PeerAndre P KengnePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 2, p e0246131 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kim A Nguyen Nasheeta Peer Andre P Kengne Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.
description	<h4>Background</h4>Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV.<h4>Methods</h4>In this cross-sectional study, HIV-infected adults were randomly recruited across 17 HIV clinics in the Western Cape Province. Homeostatic model assessment for insulin resistance (HOMA-IR), hypertension, diabetes, metabolic syndrome by Joint Interim Statement criteria (JIS-MS), a ≥5% and ≥10% predicted risk for a CVD event within 10 years by the Framingham risk score (10-years-CVD risk) were computed. Associations between GGT and cardio-metabolic trait were explored using linear and binomial logistic regressions adjusted for age, gender, lifestyle behaviours and HIV-related characteristics.<h4>Results</h4>Among 709 participants (561 women, mean age 38.6 years), log-GGT was positively associated with waist circumference (β=2.75; p<0.001), diastolic blood pressure (β=1.65; p=0.006), total cholesterol (β=0.21; p<0.001), low-density lipoprotein-cholesterol (β=0.16; p<0.001), high-density lipoprotein-cholesterol and log-triglycerides (both β=0.12; p<0.001), fasting plasma glucose (β=0.19; p=0.031), 2-hour-post-glucose-load plasma glucose (β=0.26; p=0.007), HOMA-IR (β=0.13; p=0.001), log-high-sensitivity C-reactive-protein (β=0.3; p<0.001) in linear regression analyses; with hypertension [OR=1.41 (95%CI, 1.13-1.75); p=0.001], JIS-MS [OR=1.33 (1.05-1.68); p=0.016], ≥5% 10-year-CVD risk [OR=1.55 (1.24-1.9400); p<0.001] and ≥10% 10-year-CVD risk [OR=1.56 (1.08-2.23); p=0.016] but not with diabetes [OR=1.24 (0.88-1.71), p=0.205] in logistic regression analyses.<h4>Conclusions</h4>In this study, GGT levels were associated with cardio-metabolic variables independent of HIV specific attributes. If confirmed in longitudinal studies, GGT evaluation maybe included in CVD risk monitoring strategies in people living with HIV.
format	article
author	Kim A Nguyen Nasheeta Peer Andre P Kengne
author_facet	Kim A Nguyen Nasheeta Peer Andre P Kengne
author_sort	Kim A Nguyen
title	Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.
title_short	Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.
title_full	Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.
title_fullStr	Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.
title_full_unstemmed	Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.
title_sort	associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with hiv infection in south africa.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1ab4246431b9499fb2fc19381af9b259
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Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.

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