Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy

Lisa R Koenig,1 Russell Rosenblatt,2 Rahil M Patel,3 Yiyuan Wu,4 Thanos D Papakostas,1 Anton Orlin,1 Robison V Paul Chan,1 Szilard Kiss,1 Donald J D’Amico,1 Sonal Kumar,2 Mrinali P Gupta1 1Department...

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Autores principales:	Koenig LR, Rosenblatt R, Patel RM, Wu Y, Papakostas TD, Orlin A, Chan RVP, Kiss S, D'Amico DJ, Kumar S, Gupta MP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	cirrhosis diabetes mellitus retinopathy hepatitis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1ab4557a384948d6b4f59ada1309df29
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spelling	oai:doaj.org-article:1ab4557a384948d6b4f59ada1309df292021-12-02T11:38:09ZComorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy1177-5483https://doaj.org/article/1ab4557a384948d6b4f59ada1309df292019-09-01T00:00:00Zhttps://www.dovepress.com/comorbid-hepatitis-c-does-not-modulate-prevalence-or-severity-of-diabe-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Lisa R Koenig,1 Russell Rosenblatt,2 Rahil M Patel,3 Yiyuan Wu,4 Thanos D Papakostas,1 Anton Orlin,1 Robison V Paul Chan,1 Szilard Kiss,1 Donald J D’Amico,1 Sonal Kumar,2 Mrinali P Gupta1 1Department of Ophthalmology, Weill Cornell Medicine, New York, NY, USA; 2Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, USA; 3Columbia College of Columbia University in the City of New York, New York, NY, USA; 4Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, USACorrespondence: Mrinali P GuptaDepartment of Ophthalmology, Weill Cornell Medicine, 1305 York Avenue, 11th Floor, New York, NY 10021, USATel +1 646 962 2217Fax +1 646 962 0600Email mrp9003@med.cornell.eduPurpose: There are limited and conflicting data regarding the impact of comorbid hepatitis C virus (HCV) infection on diabetic retinopathy (DR). This study sought to compare the prevalence and severity of DR among patients with diabetes mellitus (DM) with and without HCV.Patients and methods: This was a retrospective, case–control study of patients with DM comparing 120 patients with comorbid HCV and 120 age-matched controls. DR prevalence and several measures of severity were compared between groups. Subgroup analyses were performed among HCV patients with cirrhosis, comorbid HIV, or history of treatment with interferon. Statistical analysis for between-group comparisons utilized both univariate and multivariate analyses.Results: Cases and controls exhibited similar baseline characteristics: average hemoglobin A1c, DM duration, and age (p>0.05). Among cases and controls, there was no difference in DR prevalence (35.8% versus 42.5%, respectively, p=0.29) or severity (p>0.05). Within the HCV subgroup, DR severity was reduced in patients with HIV or cirrhosis. However, multivariate analysis identified reduced DM duration in these subgroups as the primary contributor to lesser DR severity, rather than HIV or cirrhosis.Conclusion: In this study, comorbid HCV did not modulate the prevalence or severity of DR among patients with DM. These findings may inform clinical monitoring among HCV-positive diabetics undergoing ophthalmic evaluation.Keywords: cirrhosis, diabetes mellitus, retinopathy, hepatitis  Koenig LRRosenblatt RPatel RMWu YPapakostas TDOrlin AChan RVPKiss SD'Amico DJKumar SGupta MPDove Medical Pressarticlecirrhosisdiabetes mellitusretinopathyhepatitisOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1681-1687 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cirrhosis diabetes mellitus retinopathy hepatitis Ophthalmology RE1-994
spellingShingle	cirrhosis diabetes mellitus retinopathy hepatitis Ophthalmology RE1-994 Koenig LR Rosenblatt R Patel RM Wu Y Papakostas TD Orlin A Chan RVP Kiss S D'Amico DJ Kumar S Gupta MP Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy
description	Lisa R Koenig,1 Russell Rosenblatt,2 Rahil M Patel,3 Yiyuan Wu,4 Thanos D Papakostas,1 Anton Orlin,1 Robison V Paul Chan,1 Szilard Kiss,1 Donald J D’Amico,1 Sonal Kumar,2 Mrinali P Gupta1 1Department of Ophthalmology, Weill Cornell Medicine, New York, NY, USA; 2Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, USA; 3Columbia College of Columbia University in the City of New York, New York, NY, USA; 4Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, USACorrespondence: Mrinali P GuptaDepartment of Ophthalmology, Weill Cornell Medicine, 1305 York Avenue, 11th Floor, New York, NY 10021, USATel +1 646 962 2217Fax +1 646 962 0600Email mrp9003@med.cornell.eduPurpose: There are limited and conflicting data regarding the impact of comorbid hepatitis C virus (HCV) infection on diabetic retinopathy (DR). This study sought to compare the prevalence and severity of DR among patients with diabetes mellitus (DM) with and without HCV.Patients and methods: This was a retrospective, case–control study of patients with DM comparing 120 patients with comorbid HCV and 120 age-matched controls. DR prevalence and several measures of severity were compared between groups. Subgroup analyses were performed among HCV patients with cirrhosis, comorbid HIV, or history of treatment with interferon. Statistical analysis for between-group comparisons utilized both univariate and multivariate analyses.Results: Cases and controls exhibited similar baseline characteristics: average hemoglobin A1c, DM duration, and age (p>0.05). Among cases and controls, there was no difference in DR prevalence (35.8% versus 42.5%, respectively, p=0.29) or severity (p>0.05). Within the HCV subgroup, DR severity was reduced in patients with HIV or cirrhosis. However, multivariate analysis identified reduced DM duration in these subgroups as the primary contributor to lesser DR severity, rather than HIV or cirrhosis.Conclusion: In this study, comorbid HCV did not modulate the prevalence or severity of DR among patients with DM. These findings may inform clinical monitoring among HCV-positive diabetics undergoing ophthalmic evaluation.Keywords: cirrhosis, diabetes mellitus, retinopathy, hepatitis
format	article
author	Koenig LR Rosenblatt R Patel RM Wu Y Papakostas TD Orlin A Chan RVP Kiss S D'Amico DJ Kumar S Gupta MP
author_facet	Koenig LR Rosenblatt R Patel RM Wu Y Papakostas TD Orlin A Chan RVP Kiss S D'Amico DJ Kumar S Gupta MP
author_sort	Koenig LR
title	Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy
title_short	Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy
title_full	Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy
title_fullStr	Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy
title_full_unstemmed	Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy
title_sort	comorbid hepatitis c does not modulate prevalence or severity of diabetic retinopathy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/1ab4557a384948d6b4f59ada1309df29
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Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy

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