Structures in G proteins important for subtype selective receptor binding and subsequent activation

With chimeric approach and biophysical (FRET) techniques, Jelinek, Mösslein & Bünemann elucidate coupling selectivity determinants of G proteins for two Gq-coupled receptors. They conclude that various regions, especially outside of the C-terminal tail of the Gα subunit, collectively affect G-pr...

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Autores principales:	Volker Jelinek, Nadja Mösslein, Moritz Bünemann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1ab50e3107bc4d848ea8d927ed419368
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spelling	oai:doaj.org-article:1ab50e3107bc4d848ea8d927ed4193682021-12-02T16:53:10ZStructures in G proteins important for subtype selective receptor binding and subsequent activation10.1038/s42003-021-02143-92399-3642https://doaj.org/article/1ab50e3107bc4d848ea8d927ed4193682021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02143-9https://doaj.org/toc/2399-3642With chimeric approach and biophysical (FRET) techniques, Jelinek, Mösslein & Bünemann elucidate coupling selectivity determinants of G proteins for two Gq-coupled receptors. They conclude that various regions, especially outside of the C-terminal tail of the Gα subunit, collectively affect G-protein-coupling selectivity.Volker JelinekNadja MössleinMoritz BünemannNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Volker Jelinek Nadja Mösslein Moritz Bünemann Structures in G proteins important for subtype selective receptor binding and subsequent activation
description	With chimeric approach and biophysical (FRET) techniques, Jelinek, Mösslein & Bünemann elucidate coupling selectivity determinants of G proteins for two Gq-coupled receptors. They conclude that various regions, especially outside of the C-terminal tail of the Gα subunit, collectively affect G-protein-coupling selectivity.
format	article
author	Volker Jelinek Nadja Mösslein Moritz Bünemann
author_facet	Volker Jelinek Nadja Mösslein Moritz Bünemann
author_sort	Volker Jelinek
title	Structures in G proteins important for subtype selective receptor binding and subsequent activation
title_short	Structures in G proteins important for subtype selective receptor binding and subsequent activation
title_full	Structures in G proteins important for subtype selective receptor binding and subsequent activation
title_fullStr	Structures in G proteins important for subtype selective receptor binding and subsequent activation
title_full_unstemmed	Structures in G proteins important for subtype selective receptor binding and subsequent activation
title_sort	structures in g proteins important for subtype selective receptor binding and subsequent activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ab50e3107bc4d848ea8d927ed419368
work_keys_str_mv	AT volkerjelinek structuresingproteinsimportantforsubtypeselectivereceptorbindingandsubsequentactivation AT nadjamosslein structuresingproteinsimportantforsubtypeselectivereceptorbindingandsubsequentactivation AT moritzbunemann structuresingproteinsimportantforsubtypeselectivereceptorbindingandsubsequentactivation
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Structures in G proteins important for subtype selective receptor binding and subsequent activation

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