Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.

This study aimed to investigate whether interindividual differences in autonomic inhibitory control predict safety learning and fear extinction in an interoceptive fear conditioning paradigm. Data from a previously reported study (N = 40) were extended (N = 17) and re-analyzed to test whether health...

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Autores principales:	Meike Pappens, Mathias Schroijen, Stefan Sütterlin, Elyn Smets, Omer Van den Bergh, Julian F Thayer, Ilse Van Diest
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ab5a6ef64ac498a8376dc399b9091a4
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spelling	oai:doaj.org-article:1ab5a6ef64ac498a8376dc399b9091a42021-11-25T06:02:11ZResting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.1932-620310.1371/journal.pone.0105054https://doaj.org/article/1ab5a6ef64ac498a8376dc399b9091a42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25181542/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This study aimed to investigate whether interindividual differences in autonomic inhibitory control predict safety learning and fear extinction in an interoceptive fear conditioning paradigm. Data from a previously reported study (N = 40) were extended (N = 17) and re-analyzed to test whether healthy participants' resting heart rate variability (HRV) - a proxy of cardiac vagal tone - predicts learning performance. The conditioned stimulus (CS) was a slight sensation of breathlessness induced by a flow resistor, the unconditioned stimulus (US) was an aversive short-lasting suffocation experience induced by a complete occlusion of the breathing circuitry. During acquisition, the paired group received 6 paired CS-US presentations; the control group received 6 explicitly unpaired CS-US presentations. In the extinction phase, both groups were exposed to 6 CS-only presentations. Measures included startle blink EMG, skin conductance responses (SCR) and US-expectancy ratings. Resting HRV significantly predicted the startle blink EMG learning curves both during acquisition and extinction. In the unpaired group, higher levels of HRV at rest predicted safety learning to the CS during acquisition. In the paired group, higher levels of HRV were associated with better extinction. Our findings suggest that the strength or integrity of prefrontal inhibitory mechanisms involved in safety- and extinction learning can be indexed by HRV at rest.Meike PappensMathias SchroijenStefan SütterlinElyn SmetsOmer Van den BerghJulian F ThayerIlse Van DiestPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e105054 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meike Pappens Mathias Schroijen Stefan Sütterlin Elyn Smets Omer Van den Bergh Julian F Thayer Ilse Van Diest Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.
description	This study aimed to investigate whether interindividual differences in autonomic inhibitory control predict safety learning and fear extinction in an interoceptive fear conditioning paradigm. Data from a previously reported study (N = 40) were extended (N = 17) and re-analyzed to test whether healthy participants' resting heart rate variability (HRV) - a proxy of cardiac vagal tone - predicts learning performance. The conditioned stimulus (CS) was a slight sensation of breathlessness induced by a flow resistor, the unconditioned stimulus (US) was an aversive short-lasting suffocation experience induced by a complete occlusion of the breathing circuitry. During acquisition, the paired group received 6 paired CS-US presentations; the control group received 6 explicitly unpaired CS-US presentations. In the extinction phase, both groups were exposed to 6 CS-only presentations. Measures included startle blink EMG, skin conductance responses (SCR) and US-expectancy ratings. Resting HRV significantly predicted the startle blink EMG learning curves both during acquisition and extinction. In the unpaired group, higher levels of HRV at rest predicted safety learning to the CS during acquisition. In the paired group, higher levels of HRV were associated with better extinction. Our findings suggest that the strength or integrity of prefrontal inhibitory mechanisms involved in safety- and extinction learning can be indexed by HRV at rest.
format	article
author	Meike Pappens Mathias Schroijen Stefan Sütterlin Elyn Smets Omer Van den Bergh Julian F Thayer Ilse Van Diest
author_facet	Meike Pappens Mathias Schroijen Stefan Sütterlin Elyn Smets Omer Van den Bergh Julian F Thayer Ilse Van Diest
author_sort	Meike Pappens
title	Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.
title_short	Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.
title_full	Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.
title_fullStr	Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.
title_full_unstemmed	Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.
title_sort	resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1ab5a6ef64ac498a8376dc399b9091a4
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Resting heart rate variability predicts safety learning and fear extinction in an interoceptive fear conditioning paradigm.

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