Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.

Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency...

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Autores principales: Andreas Binder, Denisa May, Ralf Baron, Christoph Maier, Thomas R Tölle, Rolf-Detlef Treede, Achim Berthele, Frank Faltraco, Herta Flor, Janne Gierthmühlen, Sierk Haenisch, Volker Huge, Walter Magerl, Christian Maihöfner, Helmut Richter, Roman Rolke, Andrea Scherens, Nurcan Uçeyler, Mike Ufer, Gunnar Wasner, Jihong Zhu, Ingolf Cascorbi
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spelling oai:doaj.org-article:1ab5f65f00504b0c8e7b07b406db73022021-11-18T06:56:40ZTransient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.1932-620310.1371/journal.pone.0017387https://doaj.org/article/1ab5f65f00504b0c8e7b07b406db73022011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21468319/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p = 0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p = 0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p = 0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients.Andreas BinderDenisa MayRalf BaronChristoph MaierThomas R TölleRolf-Detlef TreedeAchim BertheleFrank FaltracoHerta FlorJanne GierthmühlenSierk HaenischVolker HugeWalter MagerlChristian MaihöfnerHelmut RichterRoman RolkeAndrea ScherensNurcan UçeylerMike UferGunnar WasnerJihong ZhuIngolf CascorbiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17387 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Andreas Binder
Denisa May
Ralf Baron
Christoph Maier
Thomas R Tölle
Rolf-Detlef Treede
Achim Berthele
Frank Faltraco
Herta Flor
Janne Gierthmühlen
Sierk Haenisch
Volker Huge
Walter Magerl
Christian Maihöfner
Helmut Richter
Roman Rolke
Andrea Scherens
Nurcan Uçeyler
Mike Ufer
Gunnar Wasner
Jihong Zhu
Ingolf Cascorbi
Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
description Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p = 0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p = 0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p = 0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients.
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author Andreas Binder
Denisa May
Ralf Baron
Christoph Maier
Thomas R Tölle
Rolf-Detlef Treede
Achim Berthele
Frank Faltraco
Herta Flor
Janne Gierthmühlen
Sierk Haenisch
Volker Huge
Walter Magerl
Christian Maihöfner
Helmut Richter
Roman Rolke
Andrea Scherens
Nurcan Uçeyler
Mike Ufer
Gunnar Wasner
Jihong Zhu
Ingolf Cascorbi
author_facet Andreas Binder
Denisa May
Ralf Baron
Christoph Maier
Thomas R Tölle
Rolf-Detlef Treede
Achim Berthele
Frank Faltraco
Herta Flor
Janne Gierthmühlen
Sierk Haenisch
Volker Huge
Walter Magerl
Christian Maihöfner
Helmut Richter
Roman Rolke
Andrea Scherens
Nurcan Uçeyler
Mike Ufer
Gunnar Wasner
Jihong Zhu
Ingolf Cascorbi
author_sort Andreas Binder
title Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
title_short Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
title_full Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
title_fullStr Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
title_full_unstemmed Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
title_sort transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/1ab5f65f00504b0c8e7b07b406db7302
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