IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)

Fifty-four patients with different clinical course (acute and protracted forms) of community-acquired pneumonia (CAP), were studied for interleukin-8 (IL-8) contents in blood serum and its production levels (spontaneous and PHA-stimulated), depending on the IL-8 gene polymorphism at the 251 T → A lo...

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Autores principales:	L. F. Aznabaeva, L. S. Kozyreva, T. V. Victorova, V. I. Nikulicheva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	community-acquired pneumonia interleukin-8 polymorphism of il-8 (locus of 251 t→a) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1ab798bfb7984bdab56c04fb09fa14a9
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spelling	oai:doaj.org-article:1ab798bfb7984bdab56c04fb09fa14a92021-11-18T08:03:38ZIL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)1563-06252313-741X10.15789/1563-0625-2010-4-5-355-360https://doaj.org/article/1ab798bfb7984bdab56c04fb09fa14a92014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/183https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFifty-four patients with different clinical course (acute and protracted forms) of community-acquired pneumonia (CAP), were studied for interleukin-8 (IL-8) contents in blood serum and its production levels (spontaneous and PHA-stimulated), depending on the IL-8 gene polymorphism at the 251 T → A locus. Employing the data about immunogenetic differences, we have shown some associations between IL-8 production, depending on clinical outcome (adequate responders vs poor response to medication in acute pneumonia). Both in acute and chronic forms of pneumonia, poor response to therapy was associated with decreased reserve capacity of IL-8 production, and a downward trend of cytokine concentration in blood serum. It was revealed that the CAP patients with poor response to treatment exhibit deficient production of IL-8 associated with homozygous AA genotype at the -251 T/A locus of IL-8 gene.L. F. AznabaevaL. S. KozyrevaT. V. VictorovaV. I. NikulichevaSPb RAACIarticlecommunity-acquired pneumoniainterleukin-8polymorphism of il-8 (locus of 251 t→a)Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 355-360 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	community-acquired pneumonia interleukin-8 polymorphism of il-8 (locus of 251 t→a) Immunologic diseases. Allergy RC581-607
spellingShingle	community-acquired pneumonia interleukin-8 polymorphism of il-8 (locus of 251 t→a) Immunologic diseases. Allergy RC581-607 L. F. Aznabaeva L. S. Kozyreva T. V. Victorova V. I. Nikulicheva IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)
description	Fifty-four patients with different clinical course (acute and protracted forms) of community-acquired pneumonia (CAP), were studied for interleukin-8 (IL-8) contents in blood serum and its production levels (spontaneous and PHA-stimulated), depending on the IL-8 gene polymorphism at the 251 T → A locus. Employing the data about immunogenetic differences, we have shown some associations between IL-8 production, depending on clinical outcome (adequate responders vs poor response to medication in acute pneumonia). Both in acute and chronic forms of pneumonia, poor response to therapy was associated with decreased reserve capacity of IL-8 production, and a downward trend of cytokine concentration in blood serum. It was revealed that the CAP patients with poor response to treatment exhibit deficient production of IL-8 associated with homozygous AA genotype at the -251 T/A locus of IL-8 gene.
format	article
author	L. F. Aznabaeva L. S. Kozyreva T. V. Victorova V. I. Nikulicheva
author_facet	L. F. Aznabaeva L. S. Kozyreva T. V. Victorova V. I. Nikulicheva
author_sort	L. F. Aznabaeva
title	IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)
title_short	IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)
title_full	IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)
title_fullStr	IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)
title_full_unstemmed	IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)
title_sort	il-8 chemotactic factor in patients with community-acquired pneumonia and features of il-8 gene polymorphism (251 t/а)
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1ab798bfb7984bdab56c04fb09fa14a9
work_keys_str_mv	AT lfaznabaeva il8chemotacticfactorinpatientswithcommunityacquiredpneumoniaandfeaturesofil8genepolymorphism251ta AT lskozyreva il8chemotacticfactorinpatientswithcommunityacquiredpneumoniaandfeaturesofil8genepolymorphism251ta AT tvvictorova il8chemotacticfactorinpatientswithcommunityacquiredpneumoniaandfeaturesofil8genepolymorphism251ta AT vinikulicheva il8chemotacticfactorinpatientswithcommunityacquiredpneumoniaandfeaturesofil8genepolymorphism251ta
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IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)

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