Systems analysis of intracellular pH vulnerabilities for cancer therapy

Tumors often exhibit a pH gradient, with an acidic extracellular space and alkaline cytoplasm. Here the authors develop a computational model to show how alkaline pHi supports changes inherent to cancer cell metabolism and acidification disables these adaptations, and demonstrate the effect of acidi...

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Autores principales:	Erez Persi, Miquel Duran-Frigola, Mehdi Damaghi, William R. Roush, Patrick Aloy, John L. Cleveland, Robert J. Gillies, Eytan Ruppin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ab8080281ad4e038d81d0b32f34e808
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spelling	oai:doaj.org-article:1ab8080281ad4e038d81d0b32f34e8082021-12-02T17:31:26ZSystems analysis of intracellular pH vulnerabilities for cancer therapy10.1038/s41467-018-05261-x2041-1723https://doaj.org/article/1ab8080281ad4e038d81d0b32f34e8082018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05261-xhttps://doaj.org/toc/2041-1723Tumors often exhibit a pH gradient, with an acidic extracellular space and alkaline cytoplasm. Here the authors develop a computational model to show how alkaline pHi supports changes inherent to cancer cell metabolism and acidification disables these adaptations, and demonstrate the effect of acidic pHi on breast cancer cell survival.Erez PersiMiquel Duran-FrigolaMehdi DamaghiWilliam R. RoushPatrick AloyJohn L. ClevelandRobert J. GilliesEytan RuppinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erez Persi Miquel Duran-Frigola Mehdi Damaghi William R. Roush Patrick Aloy John L. Cleveland Robert J. Gillies Eytan Ruppin Systems analysis of intracellular pH vulnerabilities for cancer therapy
description	Tumors often exhibit a pH gradient, with an acidic extracellular space and alkaline cytoplasm. Here the authors develop a computational model to show how alkaline pHi supports changes inherent to cancer cell metabolism and acidification disables these adaptations, and demonstrate the effect of acidic pHi on breast cancer cell survival.
format	article
author	Erez Persi Miquel Duran-Frigola Mehdi Damaghi William R. Roush Patrick Aloy John L. Cleveland Robert J. Gillies Eytan Ruppin
author_facet	Erez Persi Miquel Duran-Frigola Mehdi Damaghi William R. Roush Patrick Aloy John L. Cleveland Robert J. Gillies Eytan Ruppin
author_sort	Erez Persi
title	Systems analysis of intracellular pH vulnerabilities for cancer therapy
title_short	Systems analysis of intracellular pH vulnerabilities for cancer therapy
title_full	Systems analysis of intracellular pH vulnerabilities for cancer therapy
title_fullStr	Systems analysis of intracellular pH vulnerabilities for cancer therapy
title_full_unstemmed	Systems analysis of intracellular pH vulnerabilities for cancer therapy
title_sort	systems analysis of intracellular ph vulnerabilities for cancer therapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1ab8080281ad4e038d81d0b32f34e808
work_keys_str_mv	AT erezpersi systemsanalysisofintracellularphvulnerabilitiesforcancertherapy AT miquelduranfrigola systemsanalysisofintracellularphvulnerabilitiesforcancertherapy AT mehdidamaghi systemsanalysisofintracellularphvulnerabilitiesforcancertherapy AT williamrroush systemsanalysisofintracellularphvulnerabilitiesforcancertherapy AT patrickaloy systemsanalysisofintracellularphvulnerabilitiesforcancertherapy AT johnlcleveland systemsanalysisofintracellularphvulnerabilitiesforcancertherapy AT robertjgillies systemsanalysisofintracellularphvulnerabilitiesforcancertherapy AT eytanruppin systemsanalysisofintracellularphvulnerabilitiesforcancertherapy
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Systems analysis of intracellular pH vulnerabilities for cancer therapy

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