Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer

Cancer is a major cause of death, affecting human life in both developed and developing countries. Numerous antitumor agents exist but their toxicity and low efficacy limits their utility. Furthermore, the complex pathophysiological mechanisms of cancer, serious side effects and poor prognosis restr...

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Autores principales:	Noor Rahman, Haroon Khan, Asad Zia, Asifullah Khan, Sajad Fakhri, Michael Aschner, Karim Gul, Luciano Saso
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flavonoids cancer p53 Bcl-2 pharmacology therapeutic target Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/1abe71db09794f6fb5b542cc5c1f1826
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spelling	oai:doaj.org-article:1abe71db09794f6fb5b542cc5c1f18262021-11-11T16:48:12ZBcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer10.3390/ijms2221113151422-00671661-6596https://doaj.org/article/1abe71db09794f6fb5b542cc5c1f18262021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11315https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cancer is a major cause of death, affecting human life in both developed and developing countries. Numerous antitumor agents exist but their toxicity and low efficacy limits their utility. Furthermore, the complex pathophysiological mechanisms of cancer, serious side effects and poor prognosis restrict the administration of available cancer therapies. Thus, developing novel therapeutic agents are required towards a simultaneous targeting of major dysregulated signaling mediators in cancer etiology, while possessing lower side effects. In this line, the plant kingdom is introduced as a rich source of active phytochemicals. The secondary metabolites produced by plants could potentially regulate several dysregulated pathways in cancer. Among the secondary metabolites, flavonoids are hopeful phytochemicals with established biological activities and minimal side effects. Flavonoids inhibit B-cell lymphoma 2 (Bcl-2) via the p53 signaling pathway, which is a significant apoptotic target in many cancer types, hence suppressing a major dysregulated pathway in cancer. To date, there have been no studies reported which extensively highlight the role of flavonoids and especially the different classes of flavonoids in the modulation of Bcl-2 in the P53 signaling pathway. Herein, we discuss the modulation of Bcl-2 in the p53 signaling pathway by different classes of flavonoids and highlight different mechanisms through which this modulation can occur. This study will provide a rationale for the use of flavonoids against different cancers paving a new mechanistic-based approach to cancer therapy.Noor RahmanHaroon KhanAsad ZiaAsifullah KhanSajad FakhriMichael AschnerKarim GulLuciano SasoMDPI AGarticleflavonoidscancerp53Bcl-2pharmacologytherapeutic targetBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11315, p 11315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoids cancer p53 Bcl-2 pharmacology therapeutic target Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	flavonoids cancer p53 Bcl-2 pharmacology therapeutic target Biology (General) QH301-705.5 Chemistry QD1-999 Noor Rahman Haroon Khan Asad Zia Asifullah Khan Sajad Fakhri Michael Aschner Karim Gul Luciano Saso Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer
description	Cancer is a major cause of death, affecting human life in both developed and developing countries. Numerous antitumor agents exist but their toxicity and low efficacy limits their utility. Furthermore, the complex pathophysiological mechanisms of cancer, serious side effects and poor prognosis restrict the administration of available cancer therapies. Thus, developing novel therapeutic agents are required towards a simultaneous targeting of major dysregulated signaling mediators in cancer etiology, while possessing lower side effects. In this line, the plant kingdom is introduced as a rich source of active phytochemicals. The secondary metabolites produced by plants could potentially regulate several dysregulated pathways in cancer. Among the secondary metabolites, flavonoids are hopeful phytochemicals with established biological activities and minimal side effects. Flavonoids inhibit B-cell lymphoma 2 (Bcl-2) via the p53 signaling pathway, which is a significant apoptotic target in many cancer types, hence suppressing a major dysregulated pathway in cancer. To date, there have been no studies reported which extensively highlight the role of flavonoids and especially the different classes of flavonoids in the modulation of Bcl-2 in the P53 signaling pathway. Herein, we discuss the modulation of Bcl-2 in the p53 signaling pathway by different classes of flavonoids and highlight different mechanisms through which this modulation can occur. This study will provide a rationale for the use of flavonoids against different cancers paving a new mechanistic-based approach to cancer therapy.
format	article
author	Noor Rahman Haroon Khan Asad Zia Asifullah Khan Sajad Fakhri Michael Aschner Karim Gul Luciano Saso
author_facet	Noor Rahman Haroon Khan Asad Zia Asifullah Khan Sajad Fakhri Michael Aschner Karim Gul Luciano Saso
author_sort	Noor Rahman
title	Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer
title_short	Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer
title_full	Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer
title_fullStr	Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer
title_full_unstemmed	Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer
title_sort	bcl-2 modulation in p53 signaling pathway by flavonoids: a potential strategy towards the treatment of cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1abe71db09794f6fb5b542cc5c1f1826
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Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer

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