Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in protecting kidney parenchyma against injury.

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Detalles Bibliográficos
Autores principales: Milica Bozic, Maite Caus, Raul R. Rodrigues-Diez, Neus Pedraza, Marta Ruiz-Ortega, Eloi Garí, Pilar Gallel, Maria José Panadés, Ana Martinez, Elvira Fernández, José Manuel Valdivielso
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1abf8b1a32e645768f299becb7117c14
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Descripción
Sumario:Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in protecting kidney parenchyma against injury.