Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in protecting kidney parenchyma against injury.

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Autores principales:	Milica Bozic, Maite Caus, Raul R. Rodrigues-Diez, Neus Pedraza, Marta Ruiz-Ortega, Eloi Garí, Pilar Gallel, Maria José Panadés, Ana Martinez, Elvira Fernández, José Manuel Valdivielso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1abf8b1a32e645768f299becb7117c14
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spelling	oai:doaj.org-article:1abf8b1a32e645768f299becb7117c142021-12-02T17:33:14ZProtective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis10.1038/s41467-020-15732-92041-1723https://doaj.org/article/1abf8b1a32e645768f299becb7117c142020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15732-9https://doaj.org/toc/2041-1723Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in protecting kidney parenchyma against injury.Milica BozicMaite CausRaul R. Rodrigues-DiezNeus PedrazaMarta Ruiz-OrtegaEloi GaríPilar GallelMaria José PanadésAna MartinezElvira FernándezJosé Manuel ValdivielsoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Milica Bozic Maite Caus Raul R. Rodrigues-Diez Neus Pedraza Marta Ruiz-Ortega Eloi Garí Pilar Gallel Maria José Panadés Ana Martinez Elvira Fernández José Manuel Valdivielso Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
description	Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in protecting kidney parenchyma against injury.
format	article
author	Milica Bozic Maite Caus Raul R. Rodrigues-Diez Neus Pedraza Marta Ruiz-Ortega Eloi Garí Pilar Gallel Maria José Panadés Ana Martinez Elvira Fernández José Manuel Valdivielso
author_facet	Milica Bozic Maite Caus Raul R. Rodrigues-Diez Neus Pedraza Marta Ruiz-Ortega Eloi Garí Pilar Gallel Maria José Panadés Ana Martinez Elvira Fernández José Manuel Valdivielso
author_sort	Milica Bozic
title	Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
title_short	Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
title_full	Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
title_fullStr	Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
title_full_unstemmed	Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
title_sort	protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1abf8b1a32e645768f299becb7117c14
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Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

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