In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods

Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is currently a global pandemic, and there are limited laboratory studies targeting pathogen resistance. This study aimed to investigate the effect of selected disinfection products and methods on the inactivation of SARS...

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Autores principales:	Guo Xiling, Chen Yin, Wang Ling, Wu Xiaosong, Fan Jingjing, Li Fang, Zeng Xiaoyan, Ge Yiyue, Chi Ying, Cui Lunbiao, Zhang Liubo, Sun Hong, Xu Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ac0406b15a1494995ce742845bb8fdc
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spelling	oai:doaj.org-article:1ac0406b15a1494995ce742845bb8fdc2021-12-02T13:23:58ZIn vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods10.1038/s41598-021-82148-w2045-2322https://doaj.org/article/1ac0406b15a1494995ce742845bb8fdc2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82148-whttps://doaj.org/toc/2045-2322Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is currently a global pandemic, and there are limited laboratory studies targeting pathogen resistance. This study aimed to investigate the effect of selected disinfection products and methods on the inactivation of SARS-CoV-2 in the laboratory. We used quantitative suspension testing to evaluate the effectiveness of the disinfectant/method. Available chlorine of 250 mg/L, 500 mg/L, and 1000 mg/L required 20 min, 5 min, and 0.5 min to inactivate SARS-CoV-2, respectively. A 600-fold dilution of 17% concentration of di-N-decyl dimethyl ammonium bromide (283 mg/L) and the same concentration of di-N-decyl dimethyl ammonium chloride required only 0.5 min to inactivate the virus efficiently. At 30% concentration for 1 min and 40% and above for 0.5 min, ethanol could efficiently inactivate SARS-CoV-2. Heat takes approximately 30 min at 56 °C, 10 min above 70 °C, or 5 min above 90 °C to inactivate the virus. The chlorinated disinfectants, Di-N-decyl dimethyl ammonium bromide/chloride, ethanol, and heat could effectively inactivate SARS-CoV-2 in the laboratory test. The response of SARS-CoV-2 to disinfectants is very similar to that of SARS-CoV.Guo XilingChen YinWang LingWu XiaosongFan JingjingLi FangZeng XiaoyanGe YiyueChi YingCui LunbiaoZhang LiuboSun HongXu YanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guo Xiling Chen Yin Wang Ling Wu Xiaosong Fan Jingjing Li Fang Zeng Xiaoyan Ge Yiyue Chi Ying Cui Lunbiao Zhang Liubo Sun Hong Xu Yan In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods
description	Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is currently a global pandemic, and there are limited laboratory studies targeting pathogen resistance. This study aimed to investigate the effect of selected disinfection products and methods on the inactivation of SARS-CoV-2 in the laboratory. We used quantitative suspension testing to evaluate the effectiveness of the disinfectant/method. Available chlorine of 250 mg/L, 500 mg/L, and 1000 mg/L required 20 min, 5 min, and 0.5 min to inactivate SARS-CoV-2, respectively. A 600-fold dilution of 17% concentration of di-N-decyl dimethyl ammonium bromide (283 mg/L) and the same concentration of di-N-decyl dimethyl ammonium chloride required only 0.5 min to inactivate the virus efficiently. At 30% concentration for 1 min and 40% and above for 0.5 min, ethanol could efficiently inactivate SARS-CoV-2. Heat takes approximately 30 min at 56 °C, 10 min above 70 °C, or 5 min above 90 °C to inactivate the virus. The chlorinated disinfectants, Di-N-decyl dimethyl ammonium bromide/chloride, ethanol, and heat could effectively inactivate SARS-CoV-2 in the laboratory test. The response of SARS-CoV-2 to disinfectants is very similar to that of SARS-CoV.
format	article
author	Guo Xiling Chen Yin Wang Ling Wu Xiaosong Fan Jingjing Li Fang Zeng Xiaoyan Ge Yiyue Chi Ying Cui Lunbiao Zhang Liubo Sun Hong Xu Yan
author_facet	Guo Xiling Chen Yin Wang Ling Wu Xiaosong Fan Jingjing Li Fang Zeng Xiaoyan Ge Yiyue Chi Ying Cui Lunbiao Zhang Liubo Sun Hong Xu Yan
author_sort	Guo Xiling
title	In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods
title_short	In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods
title_full	In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods
title_fullStr	In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods
title_full_unstemmed	In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods
title_sort	in vitro inactivation of sars-cov-2 by commonly used disinfection products and methods
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ac0406b15a1494995ce742845bb8fdc
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In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods

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