Changes in waist circumference and the incidence of diabetes in middle-aged men and women.

<h4>Background</h4>Waist circumference (WC) is positively associated with diabetes, but the association with changes in WC (DWC) is less clear. We investigated the association between DWC and the subsequent risk of diabetes in middle-aged men and women, and evaluated the influence from c...

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Autores principales:	Tina Landsvig Berentzen, Marianne Uhre Jakobsen, Jytte Halkjaer, Anne Tjønneland, Thorkild I A Sørensen, Kim Overvad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ac0e2c8e15b4ab5b04f75b281102f60
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spelling	oai:doaj.org-article:1ac0e2c8e15b4ab5b04f75b281102f602021-11-18T06:48:38ZChanges in waist circumference and the incidence of diabetes in middle-aged men and women.1932-620310.1371/journal.pone.0023104https://doaj.org/article/1ac0e2c8e15b4ab5b04f75b281102f602011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829698/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Waist circumference (WC) is positively associated with diabetes, but the association with changes in WC (DWC) is less clear. We investigated the association between DWC and the subsequent risk of diabetes in middle-aged men and women, and evaluated the influence from concurrent changes in body mass index (DBMI).<h4>Methodology/principal findings</h4>Data on 15,577 men and 20,066 women from the Danish Diet, Cancer and Health study were analyzed. Anthropometry was assessed in 1993-97 and 1999-02. Information on diabetes was obtained from The Danish National Diabetes Register. Hazard ratios (HR) were calculated from Cox' proportional hazard models with individuals considered at risk from 1999-02 until December 31 2006. During 5.4 years of follow-up, 1,027 and 876 new cases of diabetes occurred among men and women, respectively. WC was positively associated with diabetes in both sexes also with adjustment for covariates and BMI. DWC was positively associated with diabetes in women, but not in men (HR per 5 cm change = 1.09 (1.04:1.15) in women, and 1.00 (0.94, 1.07) in men with adjustment for covariates, baseline WC, BMI and DBMI). Associations with DWC were not notably different in sub-groups stratified according to baseline WC or DBMI, or when individuals with diseases or diabetes occurring within the first years of follow-up were excluded.<h4>Conclusions/significance</h4>While this study confirmed that WC is positively associated with the risk of diabetes in middle-aged men and women, it surprisingly showed that changes in WC were not associated with the subsequent risk of diabetes in men, and only weakly positively associated with the risk of diabetes in women. Accordingly, these findings suggest that a reduction in WC may be a weak or insufficient or target for prevention of diabetes in middle-aged men and women.Tina Landsvig BerentzenMarianne Uhre JakobsenJytte HalkjaerAnne TjønnelandThorkild I A SørensenKim OvervadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23104 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tina Landsvig Berentzen Marianne Uhre Jakobsen Jytte Halkjaer Anne Tjønneland Thorkild I A Sørensen Kim Overvad Changes in waist circumference and the incidence of diabetes in middle-aged men and women.
description	<h4>Background</h4>Waist circumference (WC) is positively associated with diabetes, but the association with changes in WC (DWC) is less clear. We investigated the association between DWC and the subsequent risk of diabetes in middle-aged men and women, and evaluated the influence from concurrent changes in body mass index (DBMI).<h4>Methodology/principal findings</h4>Data on 15,577 men and 20,066 women from the Danish Diet, Cancer and Health study were analyzed. Anthropometry was assessed in 1993-97 and 1999-02. Information on diabetes was obtained from The Danish National Diabetes Register. Hazard ratios (HR) were calculated from Cox' proportional hazard models with individuals considered at risk from 1999-02 until December 31 2006. During 5.4 years of follow-up, 1,027 and 876 new cases of diabetes occurred among men and women, respectively. WC was positively associated with diabetes in both sexes also with adjustment for covariates and BMI. DWC was positively associated with diabetes in women, but not in men (HR per 5 cm change = 1.09 (1.04:1.15) in women, and 1.00 (0.94, 1.07) in men with adjustment for covariates, baseline WC, BMI and DBMI). Associations with DWC were not notably different in sub-groups stratified according to baseline WC or DBMI, or when individuals with diseases or diabetes occurring within the first years of follow-up were excluded.<h4>Conclusions/significance</h4>While this study confirmed that WC is positively associated with the risk of diabetes in middle-aged men and women, it surprisingly showed that changes in WC were not associated with the subsequent risk of diabetes in men, and only weakly positively associated with the risk of diabetes in women. Accordingly, these findings suggest that a reduction in WC may be a weak or insufficient or target for prevention of diabetes in middle-aged men and women.
format	article
author	Tina Landsvig Berentzen Marianne Uhre Jakobsen Jytte Halkjaer Anne Tjønneland Thorkild I A Sørensen Kim Overvad
author_facet	Tina Landsvig Berentzen Marianne Uhre Jakobsen Jytte Halkjaer Anne Tjønneland Thorkild I A Sørensen Kim Overvad
author_sort	Tina Landsvig Berentzen
title	Changes in waist circumference and the incidence of diabetes in middle-aged men and women.
title_short	Changes in waist circumference and the incidence of diabetes in middle-aged men and women.
title_full	Changes in waist circumference and the incidence of diabetes in middle-aged men and women.
title_fullStr	Changes in waist circumference and the incidence of diabetes in middle-aged men and women.
title_full_unstemmed	Changes in waist circumference and the incidence of diabetes in middle-aged men and women.
title_sort	changes in waist circumference and the incidence of diabetes in middle-aged men and women.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/1ac0e2c8e15b4ab5b04f75b281102f60
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Changes in waist circumference and the incidence of diabetes in middle-aged men and women.

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