Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice
Abstract Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3...
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Nature Portfolio
2017
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oai:doaj.org-article:1ac3888dcfde483ea91e5ccecb7441ba2021-12-02T12:32:15ZPaternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice10.1038/s41598-017-01811-32045-2322https://doaj.org/article/1ac3888dcfde483ea91e5ccecb7441ba2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01811-3https://doaj.org/toc/2045-2322Abstract Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spatial training for one week and assessed the transgenerational effects in the F1 offspring when they were grown to 7-m old. We found that the paternal spatial training significantly enhanced progeny’s spatial cognitive performance and synaptic transmission in wild-type mice. Among several synapse- or memory-associated proteins, we observed that the expression level of synaptotagmin 1 (SYT1) was significantly increased in the hippocampus of the paternally trained-offspring. Paternal training increased histone acetylation at the promoter of SYT1 in both fathers’ and the offspring’s hippocampus, and as well as in the fathers’ sperm. Finally, paternal spatial training for one week did not improve memory and synaptic plasticity in 3XTg AD F1 offspring. Our findings suggest paternal spatial training for one week benefits the offspring’s cognitive performance in wild-type mice with the mechanisms involving an enhanced transgenerational histone acetylation at SYT1 promoter.Shujuan ZhangXiaoguang LiZhouyi WangYanchao LiuYuan GaoLu TanEnjie LiuQiuzhi ZhouCheng XuXin WangGongping LiuHaote ChenJian-Zhi WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
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Medicine R Science Q Shujuan Zhang Xiaoguang Li Zhouyi Wang Yanchao Liu Yuan Gao Lu Tan Enjie Liu Qiuzhi Zhou Cheng Xu Xin Wang Gongping Liu Haote Chen Jian-Zhi Wang Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice |
| description |
Abstract Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spatial training for one week and assessed the transgenerational effects in the F1 offspring when they were grown to 7-m old. We found that the paternal spatial training significantly enhanced progeny’s spatial cognitive performance and synaptic transmission in wild-type mice. Among several synapse- or memory-associated proteins, we observed that the expression level of synaptotagmin 1 (SYT1) was significantly increased in the hippocampus of the paternally trained-offspring. Paternal training increased histone acetylation at the promoter of SYT1 in both fathers’ and the offspring’s hippocampus, and as well as in the fathers’ sperm. Finally, paternal spatial training for one week did not improve memory and synaptic plasticity in 3XTg AD F1 offspring. Our findings suggest paternal spatial training for one week benefits the offspring’s cognitive performance in wild-type mice with the mechanisms involving an enhanced transgenerational histone acetylation at SYT1 promoter. |
| format |
article |
| author |
Shujuan Zhang Xiaoguang Li Zhouyi Wang Yanchao Liu Yuan Gao Lu Tan Enjie Liu Qiuzhi Zhou Cheng Xu Xin Wang Gongping Liu Haote Chen Jian-Zhi Wang |
| author_facet |
Shujuan Zhang Xiaoguang Li Zhouyi Wang Yanchao Liu Yuan Gao Lu Tan Enjie Liu Qiuzhi Zhou Cheng Xu Xin Wang Gongping Liu Haote Chen Jian-Zhi Wang |
| author_sort |
Shujuan Zhang |
| title |
Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice |
| title_short |
Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice |
| title_full |
Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice |
| title_fullStr |
Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice |
| title_full_unstemmed |
Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice |
| title_sort |
paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in alzheimer’s mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/1ac3888dcfde483ea91e5ccecb7441ba |
| work_keys_str_mv |
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