Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy

Danial Mohabati,1,2 Elon HC van Dijk,1 Thomas J van Rijssen,1 Eiko K de Jong,3 Myrte B Breukink,3 Jose P Martinez-Ciriano,4 Greet Dijkman,1 Carel B Hoyng,3 Sascha Fauser,5 Suzanne Yzer,4 Camiel JF Boon1,6 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Depa...

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Autores principales:	Mohabati D, van Dijk EHC, van Rijssen TJ, de Jong EK, Breukink MB, Martinez-Ciriano JP, Dijkman G, Hoyng CB, Fauser S, Yzer S, Boon CJF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Chronic central serous chorioretinopathy photodynamic therapy posterior cystoid retinal degeneration severe phenotype therapeutic outcome Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1ac480e105f84b34b1447fb7d96f40d8
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spelling	oai:doaj.org-article:1ac480e105f84b34b1447fb7d96f40d82021-12-02T04:03:14ZClinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy1177-5483https://doaj.org/article/1ac480e105f84b34b1447fb7d96f40d82018-10-01T00:00:00Zhttps://www.dovepress.com/clinical-spectrum-of-severe-chronic-central-serous-chorioretinopathy-a-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Danial Mohabati,1,2 Elon HC van Dijk,1 Thomas J van Rijssen,1 Eiko K de Jong,3 Myrte B Breukink,3 Jose P Martinez-Ciriano,4 Greet Dijkman,1 Carel B Hoyng,3 Sascha Fauser,5 Suzanne Yzer,4 Camiel JF Boon1,6 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; 4Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, the Netherlands; 5Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 6Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple “hot spots” of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit.Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment. Keywords: chronic central serous chorioretinopathy, photodynamic therapy, posterior cystoid retinal degeneration, severe phenotype, therapeutic outcome Mohabati Dvan Dijk EHCvan Rijssen TJde Jong EKBreukink MBMartinez-Ciriano JPDijkman GHoyng CBFauser SYzer SBoon CJFDove Medical PressarticleChronic central serous chorioretinopathyphotodynamic therapyposterior cystoid retinal degenerationsevere phenotypetherapeutic outcomeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2167-2176 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic central serous chorioretinopathy photodynamic therapy posterior cystoid retinal degeneration severe phenotype therapeutic outcome Ophthalmology RE1-994
spellingShingle	Chronic central serous chorioretinopathy photodynamic therapy posterior cystoid retinal degeneration severe phenotype therapeutic outcome Ophthalmology RE1-994 Mohabati D van Dijk EHC van Rijssen TJ de Jong EK Breukink MB Martinez-Ciriano JP Dijkman G Hoyng CB Fauser S Yzer S Boon CJF Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
description	Danial Mohabati,1,2 Elon HC van Dijk,1 Thomas J van Rijssen,1 Eiko K de Jong,3 Myrte B Breukink,3 Jose P Martinez-Ciriano,4 Greet Dijkman,1 Carel B Hoyng,3 Sascha Fauser,5 Suzanne Yzer,4 Camiel JF Boon1,6 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; 4Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, the Netherlands; 5Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 6Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple “hot spots” of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit.Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment. Keywords: chronic central serous chorioretinopathy, photodynamic therapy, posterior cystoid retinal degeneration, severe phenotype, therapeutic outcome
format	article
author	Mohabati D van Dijk EHC van Rijssen TJ de Jong EK Breukink MB Martinez-Ciriano JP Dijkman G Hoyng CB Fauser S Yzer S Boon CJF
author_facet	Mohabati D van Dijk EHC van Rijssen TJ de Jong EK Breukink MB Martinez-Ciriano JP Dijkman G Hoyng CB Fauser S Yzer S Boon CJF
author_sort	Mohabati D
title	Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
title_short	Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
title_full	Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
title_fullStr	Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
title_full_unstemmed	Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
title_sort	clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1ac480e105f84b34b1447fb7d96f40d8
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Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy

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