Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)

Background: There is limited evidence on the relationship between social isolation and renal outcomes. To address this gap, this study estimated the prospective relationship of social isolation with rapid kidney function decline and the development of chronic kidney disease (CKD) in middle-aged and...

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Autores principales:	Weiran Zhou, Yang Li, Yichun Ning, Shaomin Gong, Nana Song, Bowen Zhu, Jialin Wang, Shuan Zhao, Yiqin Shi, Xiaoqiang Ding
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	social isolation chronic kidney disease glomerular filtration rate CHARLS Chinese middle-aged and older adults Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1ac78bd4eea94520a2606a7b83806678
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spelling	oai:doaj.org-article:1ac78bd4eea94520a2606a7b838066782021-12-02T08:45:22ZSocial Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)2296-858X10.3389/fmed.2021.782624https://doaj.org/article/1ac78bd4eea94520a2606a7b838066782021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.782624/fullhttps://doaj.org/toc/2296-858XBackground: There is limited evidence on the relationship between social isolation and renal outcomes. To address this gap, this study estimated the prospective relationship of social isolation with rapid kidney function decline and the development of chronic kidney disease (CKD) in middle-aged and elderly Chinese with normal kidney function.Methods: We analyzed data from 3,031 participants aged ≥ 45 years with baseline estimated glomerular filtration rates (eGFR) ≥ 60 ml/min/1.73 m2. All data were obtained from the 2011 and 2015 waves of the Chinese Longitudinal Study of Health and Retirement (CHARLS). eGFR was estimated based on a combination of serum creatinine and cystatin C. The primary outcome was rapid decline in renal function, as defined by an eGFR decrease of > 5 ml/min/1.73 m2 per year, while the secondary outcome was the development of CKD, as defined by an eGFR decrease to a level < 60 ml/min/1.73 m2.Results: During the follow-up of 4 years, 258 (8.5%) participants experienced a rapid decline in renal function, while 87 (2.9%) developed CKD. In the fully adjusted model, high social isolation was significantly related to an increased risk of experiencing a rapid decline in renal function (OR 1.805, 95% CI 1.310–2.487) and CKD onset (OR 1.842, 95% CI 1.084–3.129). Among the five components of social isolation, being unmarried, not participating in social activities, and living alone independently predicted declined renal function.Conclusions: Social isolation is significantly associated with the risk of rapid eGFR decline and CKD onset in middle-aged and older adults with normal kidney function in China.Weiran ZhouYang LiYang LiYang LiYang LiYang LiYichun NingYichun NingYichun NingYichun NingYichun NingShaomin GongShaomin GongShaomin GongShaomin GongShaomin GongNana SongNana SongNana SongNana SongNana SongBowen ZhuJialin WangJialin WangJialin WangJialin WangJialin WangShuan ZhaoShuan ZhaoShuan ZhaoShuan ZhaoShuan ZhaoYiqin ShiYiqin ShiYiqin ShiYiqin ShiYiqin ShiXiaoqiang DingXiaoqiang DingXiaoqiang DingXiaoqiang DingXiaoqiang DingFrontiers Media S.A.articlesocial isolationchronic kidney diseaseglomerular filtration rateCHARLSChinese middle-aged and older adultsMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	social isolation chronic kidney disease glomerular filtration rate CHARLS Chinese middle-aged and older adults Medicine (General) R5-920
spellingShingle	social isolation chronic kidney disease glomerular filtration rate CHARLS Chinese middle-aged and older adults Medicine (General) R5-920 Weiran Zhou Yang Li Yang Li Yang Li Yang Li Yang Li Yichun Ning Yichun Ning Yichun Ning Yichun Ning Yichun Ning Shaomin Gong Shaomin Gong Shaomin Gong Shaomin Gong Shaomin Gong Nana Song Nana Song Nana Song Nana Song Nana Song Bowen Zhu Jialin Wang Jialin Wang Jialin Wang Jialin Wang Jialin Wang Shuan Zhao Shuan Zhao Shuan Zhao Shuan Zhao Shuan Zhao Yiqin Shi Yiqin Shi Yiqin Shi Yiqin Shi Yiqin Shi Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)
description	Background: There is limited evidence on the relationship between social isolation and renal outcomes. To address this gap, this study estimated the prospective relationship of social isolation with rapid kidney function decline and the development of chronic kidney disease (CKD) in middle-aged and elderly Chinese with normal kidney function.Methods: We analyzed data from 3,031 participants aged ≥ 45 years with baseline estimated glomerular filtration rates (eGFR) ≥ 60 ml/min/1.73 m2. All data were obtained from the 2011 and 2015 waves of the Chinese Longitudinal Study of Health and Retirement (CHARLS). eGFR was estimated based on a combination of serum creatinine and cystatin C. The primary outcome was rapid decline in renal function, as defined by an eGFR decrease of > 5 ml/min/1.73 m2 per year, while the secondary outcome was the development of CKD, as defined by an eGFR decrease to a level < 60 ml/min/1.73 m2.Results: During the follow-up of 4 years, 258 (8.5%) participants experienced a rapid decline in renal function, while 87 (2.9%) developed CKD. In the fully adjusted model, high social isolation was significantly related to an increased risk of experiencing a rapid decline in renal function (OR 1.805, 95% CI 1.310–2.487) and CKD onset (OR 1.842, 95% CI 1.084–3.129). Among the five components of social isolation, being unmarried, not participating in social activities, and living alone independently predicted declined renal function.Conclusions: Social isolation is significantly associated with the risk of rapid eGFR decline and CKD onset in middle-aged and older adults with normal kidney function in China.
format	article
author	Weiran Zhou Yang Li Yang Li Yang Li Yang Li Yang Li Yichun Ning Yichun Ning Yichun Ning Yichun Ning Yichun Ning Shaomin Gong Shaomin Gong Shaomin Gong Shaomin Gong Shaomin Gong Nana Song Nana Song Nana Song Nana Song Nana Song Bowen Zhu Jialin Wang Jialin Wang Jialin Wang Jialin Wang Jialin Wang Shuan Zhao Shuan Zhao Shuan Zhao Shuan Zhao Shuan Zhao Yiqin Shi Yiqin Shi Yiqin Shi Yiqin Shi Yiqin Shi Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding
author_facet	Weiran Zhou Yang Li Yang Li Yang Li Yang Li Yang Li Yichun Ning Yichun Ning Yichun Ning Yichun Ning Yichun Ning Shaomin Gong Shaomin Gong Shaomin Gong Shaomin Gong Shaomin Gong Nana Song Nana Song Nana Song Nana Song Nana Song Bowen Zhu Jialin Wang Jialin Wang Jialin Wang Jialin Wang Jialin Wang Shuan Zhao Shuan Zhao Shuan Zhao Shuan Zhao Shuan Zhao Yiqin Shi Yiqin Shi Yiqin Shi Yiqin Shi Yiqin Shi Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding
author_sort	Weiran Zhou
title	Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)
title_short	Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)
title_full	Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)
title_fullStr	Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)
title_full_unstemmed	Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)
title_sort	social isolation is associated with rapid kidney function decline and the development of chronic kidney diseases in middle-aged and elderly adults: findings from the china health and retirement longitudinal study (charls)
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1ac78bd4eea94520a2606a7b83806678
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Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)

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