Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection

Abstract Gold nanoparticles (AuNP) dotted reduction graphene oxide (RGO-AuNP) is used as a platform for an aptamer biosensor to selectively detect 3,3′4,4′-polychlorinated biphenyls (PCB77). By anchoring aptamers onto the binding sites of RGO-AuNP and making use of the synergy effect of RGO and AuNP...

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Autores principales:	Lidong Wu, Xianbo Lu, Xiaochen Fu, Lingxia Wu, Huan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ac8e918cb9e4c5b8fce92876fb871e0
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spelling	oai:doaj.org-article:1ac8e918cb9e4c5b8fce92876fb871e02021-12-02T12:32:57ZGold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection10.1038/s41598-017-05352-72045-2322https://doaj.org/article/1ac8e918cb9e4c5b8fce92876fb871e02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05352-7https://doaj.org/toc/2045-2322Abstract Gold nanoparticles (AuNP) dotted reduction graphene oxide (RGO-AuNP) is used as a platform for an aptamer biosensor to selectively detect 3,3′4,4′-polychlorinated biphenyls (PCB77). By anchoring aptamers onto the binding sites of RGO-AuNP and making use of the synergy effect of RGO and AuNP, the RGO-AuNP based biosensor exhibits superior analytical performances to AuNP based biosensor in terms of sensitivity and repeatability. The sensitivity of RGO-AuNP based aptamers (RGO-AuNP-Ap) biosensor (226.8 μA cm−2) is nearly two times higher than that of Au based biosensors (AuNP-Ap/Au electrode, 147.2 μA cm−2). The RGO-AuNP-Ap/Au biosensor demonstrated a linear response for PCB77 concentrations between 1 pg L−1 and 10 μg L−1, with a low limit of detection (LOD) of 0.1 pg L−1. The superb LOD satisfies the exposure thresholds (uncontaminated water < 0.1 ng L−1) set out by International Agency for Research on Cancer (IARC) and the Environmental Protection Agency (EPA). The proposed biosensor can be a powerful tool for rapid, sensitive and selective detection of PCBs on site.Lidong WuXianbo LuXiaochen FuLingxia WuHuan LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lidong Wu Xianbo Lu Xiaochen Fu Lingxia Wu Huan Liu Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection
description	Abstract Gold nanoparticles (AuNP) dotted reduction graphene oxide (RGO-AuNP) is used as a platform for an aptamer biosensor to selectively detect 3,3′4,4′-polychlorinated biphenyls (PCB77). By anchoring aptamers onto the binding sites of RGO-AuNP and making use of the synergy effect of RGO and AuNP, the RGO-AuNP based biosensor exhibits superior analytical performances to AuNP based biosensor in terms of sensitivity and repeatability. The sensitivity of RGO-AuNP based aptamers (RGO-AuNP-Ap) biosensor (226.8 μA cm−2) is nearly two times higher than that of Au based biosensors (AuNP-Ap/Au electrode, 147.2 μA cm−2). The RGO-AuNP-Ap/Au biosensor demonstrated a linear response for PCB77 concentrations between 1 pg L−1 and 10 μg L−1, with a low limit of detection (LOD) of 0.1 pg L−1. The superb LOD satisfies the exposure thresholds (uncontaminated water < 0.1 ng L−1) set out by International Agency for Research on Cancer (IARC) and the Environmental Protection Agency (EPA). The proposed biosensor can be a powerful tool for rapid, sensitive and selective detection of PCBs on site.
format	article
author	Lidong Wu Xianbo Lu Xiaochen Fu Lingxia Wu Huan Liu
author_facet	Lidong Wu Xianbo Lu Xiaochen Fu Lingxia Wu Huan Liu
author_sort	Lidong Wu
title	Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection
title_short	Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection
title_full	Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection
title_fullStr	Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection
title_full_unstemmed	Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection
title_sort	gold nanoparticles dotted reduction graphene oxide nanocomposite based electrochemical aptasensor for selective, rapid, sensitive and congener-specific pcb77 detection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ac8e918cb9e4c5b8fce92876fb871e0
work_keys_str_mv	AT lidongwu goldnanoparticlesdottedreductiongrapheneoxidenanocompositebasedelectrochemicalaptasensorforselectiverapidsensitiveandcongenerspecificpcb77detection AT xianbolu goldnanoparticlesdottedreductiongrapheneoxidenanocompositebasedelectrochemicalaptasensorforselectiverapidsensitiveandcongenerspecificpcb77detection AT xiaochenfu goldnanoparticlesdottedreductiongrapheneoxidenanocompositebasedelectrochemicalaptasensorforselectiverapidsensitiveandcongenerspecificpcb77detection AT lingxiawu goldnanoparticlesdottedreductiongrapheneoxidenanocompositebasedelectrochemicalaptasensorforselectiverapidsensitiveandcongenerspecificpcb77detection AT huanliu goldnanoparticlesdottedreductiongrapheneoxidenanocompositebasedelectrochemicalaptasensorforselectiverapidsensitiveandcongenerspecificpcb77detection
_version_	1718393904757211136

Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection

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