Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor

Owing to the maximum utilization efficiency of the metal atoms, single-atom catalysts (SACs), which have higher catalytic activity and selectivity than traditional nanocatalysts, have been used as sensing materials for signal amplification and sensitive detection of biomolecules. Recently, single-at...

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Autores principales:	Jiening Wu, Yalin Wu, Liping Lu, Dongtang Zhang, Xiayan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/1ac9767c059e4deda354e9ae58555620
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spelling	oai:doaj.org-article:1ac9767c059e4deda354e9ae585556202021-11-28T04:39:31ZSingle-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor2666-831910.1016/j.talo.2021.100075https://doaj.org/article/1ac9767c059e4deda354e9ae585556202021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266683192100045Xhttps://doaj.org/toc/2666-8319Owing to the maximum utilization efficiency of the metal atoms, single-atom catalysts (SACs), which have higher catalytic activity and selectivity than traditional nanocatalysts, have been used as sensing materials for signal amplification and sensitive detection of biomolecules. Recently, single-atom Au catalysts have attracted attention. Au nanoparticles have high catalytic activity, and the loading efficiency on the support can be further increased by downsizing Au nanoparticles to single atoms. Compared with other oxide supports, the higher density of vacancies on the CeO2 surface can accommodate more Au atoms, and thereby CeO2 can stabilize more metal atoms. In this paper, we describe an electrochemical sensor based on Au–CeO2 nanocomposites for ultrasensitive and highly selective detection of H2O2 released from A549 cells by immobilizing single-atom Au on specific facets of CeO2. Due to the abundant oxygen vacancies on the surface and the strong interactive effect between Ce ions and Au atoms, this sensor displayed excellent electrochemical performance, with a detection limit of 1.4 nM. The synergistic effect of CeO2 and Au atoms also resulted in high catalytic activity and stability. This study shows that the single-atom nanozyme sensing strategy can be applied to the sensitive detection of reactive oxygen species. Thus, single-atom sensors have broad application prospects in clinical analysis and physiology.Jiening WuYalin WuLiping LuDongtang ZhangXiayan WangElsevierarticleAnalytical chemistryQD71-142ENTalanta Open, Vol 4, Iss , Pp 100075- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Analytical chemistry QD71-142
spellingShingle	Analytical chemistry QD71-142 Jiening Wu Yalin Wu Liping Lu Dongtang Zhang Xiayan Wang Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor
description	Owing to the maximum utilization efficiency of the metal atoms, single-atom catalysts (SACs), which have higher catalytic activity and selectivity than traditional nanocatalysts, have been used as sensing materials for signal amplification and sensitive detection of biomolecules. Recently, single-atom Au catalysts have attracted attention. Au nanoparticles have high catalytic activity, and the loading efficiency on the support can be further increased by downsizing Au nanoparticles to single atoms. Compared with other oxide supports, the higher density of vacancies on the CeO2 surface can accommodate more Au atoms, and thereby CeO2 can stabilize more metal atoms. In this paper, we describe an electrochemical sensor based on Au–CeO2 nanocomposites for ultrasensitive and highly selective detection of H2O2 released from A549 cells by immobilizing single-atom Au on specific facets of CeO2. Due to the abundant oxygen vacancies on the surface and the strong interactive effect between Ce ions and Au atoms, this sensor displayed excellent electrochemical performance, with a detection limit of 1.4 nM. The synergistic effect of CeO2 and Au atoms also resulted in high catalytic activity and stability. This study shows that the single-atom nanozyme sensing strategy can be applied to the sensitive detection of reactive oxygen species. Thus, single-atom sensors have broad application prospects in clinical analysis and physiology.
format	article
author	Jiening Wu Yalin Wu Liping Lu Dongtang Zhang Xiayan Wang
author_facet	Jiening Wu Yalin Wu Liping Lu Dongtang Zhang Xiayan Wang
author_sort	Jiening Wu
title	Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor
title_short	Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor
title_full	Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor
title_fullStr	Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor
title_full_unstemmed	Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor
title_sort	single-atom au catalyst loaded on ceo2: a novel single-atom nanozyme electrochemical h2o2 sensor
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1ac9767c059e4deda354e9ae58555620
work_keys_str_mv	AT jieningwu singleatomaucatalystloadedonceo2anovelsingleatomnanozymeelectrochemicalh2o2sensor AT yalinwu singleatomaucatalystloadedonceo2anovelsingleatomnanozymeelectrochemicalh2o2sensor AT lipinglu singleatomaucatalystloadedonceo2anovelsingleatomnanozymeelectrochemicalh2o2sensor AT dongtangzhang singleatomaucatalystloadedonceo2anovelsingleatomnanozymeelectrochemicalh2o2sensor AT xiayanwang singleatomaucatalystloadedonceo2anovelsingleatomnanozymeelectrochemicalh2o2sensor
_version_	1718408244585562112

Single-atom Au catalyst loaded on CeO2: A novel single-atom nanozyme electrochemical H2O2 sensor

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