Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia

Introduction: Prompt diagnosis and initiation of treatment are essential in preventing long-term renal scarring. However, increasing antibiotic resistance may delay the initiation of appropriate therapy. Methodology: A retrospective chart review was performed for patients admitted to the pediatric d...

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Autores principales:	Mohammed Abdullah Alzahrani, Heba Hassan Mohamed Sadoma, Sowmya Mathew, Saleh Alghamdi, Jonaid Ahmad Malik, Sirajudheen Anwar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	uropathogen antibiotics resistance pediatric patients Al Baha Saudi Arabia Medicine R
Acceso en línea:	https://doaj.org/article/1ac9957e571e493d98e2b97a2dcc2765
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spelling	oai:doaj.org-article:1ac9957e571e493d98e2b97a2dcc27652021-11-25T17:46:21ZRetrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia10.3390/healthcare91115642227-9032https://doaj.org/article/1ac9957e571e493d98e2b97a2dcc27652021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1564https://doaj.org/toc/2227-9032Introduction: Prompt diagnosis and initiation of treatment are essential in preventing long-term renal scarring. However, increasing antibiotic resistance may delay the initiation of appropriate therapy. Methodology: A retrospective chart review was performed for patients admitted to the pediatric department with urinary tract infection (UTI) diagnosis in a large tertiary care hospital in Al Baha, Saudi Arabia, from May 2017 to April 2018. The study included children of both sexes under the age of 14 years. Results: Out of 118 urinary bacterial samples, <i>Escherichia coli</i> was the main etiologic agent in the community- and hospital-acquired infections. The infection rate was higher in girls (68.64%) than in boys (31.36%). The commonest isolates were <i>Escherichia coli</i> (44.07%), extended-spectrum beta-lactamase-producing <i>Escherichia coli</i> (11.86%), <i>Klebsiella pneumoniae</i> (9.32%), <i>Enterococcus faecalis</i> (7.63%), methicillin-resistant <i>Staphylococcus epidermidis</i> (4.24%), and coagulase-negative <i>Staphylococci</i> (3.39%). The current study demonstrates that nitrofurantoin (19%) was the most commonly prescribed medication in the inpatient and outpatient departments, followed by trimethoprim/sulfamethoxazole (16%), amoxicillin/clavulanic acid (15%), cefuroxime (10%), azithromycin (8%), ceftriaxone (7%), and ciprofloxacin (4%), while amikacin, amoxicillin, ampicillin, cefepime, imipenem, phenoxymethylpenicillin were prescribed less commonly due to the high resistance rate. Conclusion: The microbial culture and sensitivity of the isolates from urine samples should be routine before starting antimicrobial therapy. Current knowledge of the antibiotic susceptibility patterns of uropathogens in specific geographical locations is essential for choosing an appropriate empirical antimicrobial treatment rather than reliance on recommended guidelines.Mohammed Abdullah AlzahraniHeba Hassan Mohamed SadomaSowmya MathewSaleh AlghamdiJonaid Ahmad MalikSirajudheen AnwarMDPI AGarticleuropathogenantibiotics resistancepediatric patientsAl BahaSaudi ArabiaMedicineRENHealthcare, Vol 9, Iss 1564, p 1564 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uropathogen antibiotics resistance pediatric patients Al Baha Saudi Arabia Medicine R
spellingShingle	uropathogen antibiotics resistance pediatric patients Al Baha Saudi Arabia Medicine R Mohammed Abdullah Alzahrani Heba Hassan Mohamed Sadoma Sowmya Mathew Saleh Alghamdi Jonaid Ahmad Malik Sirajudheen Anwar Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia
description	Introduction: Prompt diagnosis and initiation of treatment are essential in preventing long-term renal scarring. However, increasing antibiotic resistance may delay the initiation of appropriate therapy. Methodology: A retrospective chart review was performed for patients admitted to the pediatric department with urinary tract infection (UTI) diagnosis in a large tertiary care hospital in Al Baha, Saudi Arabia, from May 2017 to April 2018. The study included children of both sexes under the age of 14 years. Results: Out of 118 urinary bacterial samples, <i>Escherichia coli</i> was the main etiologic agent in the community- and hospital-acquired infections. The infection rate was higher in girls (68.64%) than in boys (31.36%). The commonest isolates were <i>Escherichia coli</i> (44.07%), extended-spectrum beta-lactamase-producing <i>Escherichia coli</i> (11.86%), <i>Klebsiella pneumoniae</i> (9.32%), <i>Enterococcus faecalis</i> (7.63%), methicillin-resistant <i>Staphylococcus epidermidis</i> (4.24%), and coagulase-negative <i>Staphylococci</i> (3.39%). The current study demonstrates that nitrofurantoin (19%) was the most commonly prescribed medication in the inpatient and outpatient departments, followed by trimethoprim/sulfamethoxazole (16%), amoxicillin/clavulanic acid (15%), cefuroxime (10%), azithromycin (8%), ceftriaxone (7%), and ciprofloxacin (4%), while amikacin, amoxicillin, ampicillin, cefepime, imipenem, phenoxymethylpenicillin were prescribed less commonly due to the high resistance rate. Conclusion: The microbial culture and sensitivity of the isolates from urine samples should be routine before starting antimicrobial therapy. Current knowledge of the antibiotic susceptibility patterns of uropathogens in specific geographical locations is essential for choosing an appropriate empirical antimicrobial treatment rather than reliance on recommended guidelines.
format	article
author	Mohammed Abdullah Alzahrani Heba Hassan Mohamed Sadoma Sowmya Mathew Saleh Alghamdi Jonaid Ahmad Malik Sirajudheen Anwar
author_facet	Mohammed Abdullah Alzahrani Heba Hassan Mohamed Sadoma Sowmya Mathew Saleh Alghamdi Jonaid Ahmad Malik Sirajudheen Anwar
author_sort	Mohammed Abdullah Alzahrani
title	Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia
title_short	Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia
title_full	Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia
title_fullStr	Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia
title_full_unstemmed	Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia
title_sort	retrospective analysis of antimicrobial susceptibility of uropathogens isolated from pediatric patients in tertiary hospital at al-baha region, saudi arabia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1ac9957e571e493d98e2b97a2dcc2765
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Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia

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