Evaluation of silica nanoparticle toxicity after topical exposure for 90 days

Hwa Jung Ryu,1,* Nak-won Seong,2,* Byoung Joon So,1 Heung-sik Seo,2 Jun-ho Kim,2 Jeong-Sup Hong,2 Myeong-kyu Park,2 Min-Seok Kim,2 Yu-Ri Kim,3 Kyu-Bong Cho,4 Mu yeb Seo,2 Meyoung-Kon Kim,3 Eun Ho Maeng,2 Sang Wook Son1 1Department of Dermatology, Korea University College of Medicine, Seoul, South...

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Autores principales:	Ryu HJ, Seong NW, So BJ, Seo HS, Kim JH, Hong JS, Park MK, Kim MS, Kim YR, Cho KB, Seo MY, Kim MK, Maeng EH, Son SW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1acb468e810d46308de890e02bd2fbf0
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spelling	oai:doaj.org-article:1acb468e810d46308de890e02bd2fbf02021-12-02T05:40:38ZEvaluation of silica nanoparticle toxicity after topical exposure for 90 days1178-2013https://doaj.org/article/1acb468e810d46308de890e02bd2fbf02014-12-01T00:00:00Zhttp://www.dovepress.com/evaluation-of-silica-nanoparticle-toxicity-after-topical-exposure-for--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Hwa Jung Ryu,1,* Nak-won Seong,2,* Byoung Joon So,1 Heung-sik Seo,2 Jun-ho Kim,2 Jeong-Sup Hong,2 Myeong-kyu Park,2 Min-Seok Kim,2 Yu-Ri Kim,3 Kyu-Bong Cho,4 Mu yeb Seo,2 Meyoung-Kon Kim,3 Eun Ho Maeng,2 Sang Wook Son1 1Department of Dermatology, Korea University College of Medicine, Seoul, South Korea; 2Korea Testing and Research Institute, Gyunggi-Do, South Korea; 3Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea; 4Department of Clinical Laboratory Science, Shinheung College, Uijeongbu, South Korea *These authors contributed equally to this work Abstract: Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats. Keywords: silica nanoparticles, toxicity, dermal routeRyu HJSeong NWSo BJSeo HSKim JHHong JSPark MKKim MSKim YRCho KBSeo MYKim MKMaeng EHSon SWDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 2, Pp 127-136 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ryu HJ Seong NW So BJ Seo HS Kim JH Hong JS Park MK Kim MS Kim YR Cho KB Seo MY Kim MK Maeng EH Son SW Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
description	Hwa Jung Ryu,1,* Nak-won Seong,2,* Byoung Joon So,1 Heung-sik Seo,2 Jun-ho Kim,2 Jeong-Sup Hong,2 Myeong-kyu Park,2 Min-Seok Kim,2 Yu-Ri Kim,3 Kyu-Bong Cho,4 Mu yeb Seo,2 Meyoung-Kon Kim,3 Eun Ho Maeng,2 Sang Wook Son1 1Department of Dermatology, Korea University College of Medicine, Seoul, South Korea; 2Korea Testing and Research Institute, Gyunggi-Do, South Korea; 3Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea; 4Department of Clinical Laboratory Science, Shinheung College, Uijeongbu, South Korea *These authors contributed equally to this work Abstract: Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats. Keywords: silica nanoparticles, toxicity, dermal route
format	article
author	Ryu HJ Seong NW So BJ Seo HS Kim JH Hong JS Park MK Kim MS Kim YR Cho KB Seo MY Kim MK Maeng EH Son SW
author_facet	Ryu HJ Seong NW So BJ Seo HS Kim JH Hong JS Park MK Kim MS Kim YR Cho KB Seo MY Kim MK Maeng EH Son SW
author_sort	Ryu HJ
title	Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
title_short	Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
title_full	Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
title_fullStr	Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
title_full_unstemmed	Evaluation of silica nanoparticle toxicity after topical exposure for 90 days
title_sort	evaluation of silica nanoparticle toxicity after topical exposure for 90 days
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/1acb468e810d46308de890e02bd2fbf0
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_version_	1718400279465951232

Evaluation of silica nanoparticle toxicity after topical exposure for 90 days

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