Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanced learning and memory.

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Autores principales:	Naoko Morimura, Hiroki Yasuda, Kazuhiko Yamaguchi, Kei-ichi Katayama, Minoru Hatayama, Naoko H. Tomioka, Maya Odagawa, Akiko Kamiya, Yoshimi Iwayama, Motoko Maekawa, Kazuhiko Nakamura, Hideo Matsuzaki, Masatsugu Tsujii, Kazuyuki Yamada, Takeo Yoshikawa, Jun Aruga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1acb992c3c7f417085fb67cf1cfeb33b
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spelling	oai:doaj.org-article:1acb992c3c7f417085fb67cf1cfeb33b2021-12-02T14:40:26ZAutism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice10.1038/ncomms158002041-1723https://doaj.org/article/1acb992c3c7f417085fb67cf1cfeb33b2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15800https://doaj.org/toc/2041-1723Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanced learning and memory.Naoko MorimuraHiroki YasudaKazuhiko YamaguchiKei-ichi KatayamaMinoru HatayamaNaoko H. TomiokaMaya OdagawaAkiko KamiyaYoshimi IwayamaMotoko MaekawaKazuhiko NakamuraHideo MatsuzakiMasatsugu TsujiiKazuyuki YamadaTakeo YoshikawaJun ArugaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naoko Morimura Hiroki Yasuda Kazuhiko Yamaguchi Kei-ichi Katayama Minoru Hatayama Naoko H. Tomioka Maya Odagawa Akiko Kamiya Yoshimi Iwayama Motoko Maekawa Kazuhiko Nakamura Hideo Matsuzaki Masatsugu Tsujii Kazuyuki Yamada Takeo Yoshikawa Jun Aruga Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
description	Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanced learning and memory.
format	article
author	Naoko Morimura Hiroki Yasuda Kazuhiko Yamaguchi Kei-ichi Katayama Minoru Hatayama Naoko H. Tomioka Maya Odagawa Akiko Kamiya Yoshimi Iwayama Motoko Maekawa Kazuhiko Nakamura Hideo Matsuzaki Masatsugu Tsujii Kazuyuki Yamada Takeo Yoshikawa Jun Aruga
author_facet	Naoko Morimura Hiroki Yasuda Kazuhiko Yamaguchi Kei-ichi Katayama Minoru Hatayama Naoko H. Tomioka Maya Odagawa Akiko Kamiya Yoshimi Iwayama Motoko Maekawa Kazuhiko Nakamura Hideo Matsuzaki Masatsugu Tsujii Kazuyuki Yamada Takeo Yoshikawa Jun Aruga
author_sort	Naoko Morimura
title	Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
title_short	Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
title_full	Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
title_fullStr	Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
title_full_unstemmed	Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
title_sort	autism-like behaviours and enhanced memory formation and synaptic plasticity in lrfn2/salm1-deficient mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1acb992c3c7f417085fb67cf1cfeb33b
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_version_	1718390281536012288

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

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