Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study

Abstract Objective Colloid solutions are commonly used to maintain perioperative fluid homeostasis. In regard to perioperative infant-centered care, data about the impact of colloids are rare. New data suggest a possible positive effect of hydroxyethyl starch (HES) concerning blood brain barrier. Th...

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Autores principales:	Martin A. Schick, Jonas Pippir, Manuel F. Struck, Jürgen Brugger, Winfried Neuhaus, Christian Wunder
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hydroxyethylstarch HES Human albumin Pediatric neurosurgery Volume substitution Colloid Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/1accb5b2591649c3998785538fb77001
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spelling	oai:doaj.org-article:1accb5b2591649c3998785538fb770012021-11-28T12:25:10ZComparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study10.1186/s13104-021-05836-w1756-0500https://doaj.org/article/1accb5b2591649c3998785538fb770012021-11-01T00:00:00Zhttps://doi.org/10.1186/s13104-021-05836-whttps://doaj.org/toc/1756-0500Abstract Objective Colloid solutions are commonly used to maintain perioperative fluid homeostasis. In regard to perioperative infant-centered care, data about the impact of colloids are rare. New data suggest a possible positive effect of hydroxyethyl starch (HES) concerning blood brain barrier. Therefore we conduct a retrospective single center study of children scheduled for neurosurgery, age < five with a blood loss > 10% of body blood volume, receiving either 6% HES 130/0.4 or 5% human albumin (HA). Results Out of 913 patients, 86 were included (HES = 30; HA = 56). Compared to HES [16.4 ± 9.2 ml/kg body weight (mean ± SD)] HA group received more colloid volume (25.7 ± 11.3), which had more blood loss [HA 54.8 ± 45.0; HES 30.5 ± 30.0 (%) estimated blood volume] and higher fluid balances. Fibrinogen was decreased and activated partial thromboplastin time was elevated in HA group. Urinary output, creatinine and urea levels did not differ between the two groups. Serum calcium, total protein levels were lower in HES group. HA treated infants tended to have shorter ICU and hospital stays. We conclude that none of the investigated colloid solutions were without leverage to infants. Consequently randomized controlled trials about perioperative goal-directed fluid replacement of children undergoing (neuro)-surgery with major blood loss are needed.Martin A. SchickJonas PippirManuel F. StruckJürgen BruggerWinfried NeuhausChristian WunderBMCarticleHydroxyethylstarchHESHuman albuminPediatric neurosurgeryVolume substitutionColloidMedicineRBiology (General)QH301-705.5Science (General)Q1-390ENBMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hydroxyethylstarch HES Human albumin Pediatric neurosurgery Volume substitution Colloid Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
spellingShingle	Hydroxyethylstarch HES Human albumin Pediatric neurosurgery Volume substitution Colloid Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 Martin A. Schick Jonas Pippir Manuel F. Struck Jürgen Brugger Winfried Neuhaus Christian Wunder Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
description	Abstract Objective Colloid solutions are commonly used to maintain perioperative fluid homeostasis. In regard to perioperative infant-centered care, data about the impact of colloids are rare. New data suggest a possible positive effect of hydroxyethyl starch (HES) concerning blood brain barrier. Therefore we conduct a retrospective single center study of children scheduled for neurosurgery, age < five with a blood loss > 10% of body blood volume, receiving either 6% HES 130/0.4 or 5% human albumin (HA). Results Out of 913 patients, 86 were included (HES = 30; HA = 56). Compared to HES [16.4 ± 9.2 ml/kg body weight (mean ± SD)] HA group received more colloid volume (25.7 ± 11.3), which had more blood loss [HA 54.8 ± 45.0; HES 30.5 ± 30.0 (%) estimated blood volume] and higher fluid balances. Fibrinogen was decreased and activated partial thromboplastin time was elevated in HA group. Urinary output, creatinine and urea levels did not differ between the two groups. Serum calcium, total protein levels were lower in HES group. HA treated infants tended to have shorter ICU and hospital stays. We conclude that none of the investigated colloid solutions were without leverage to infants. Consequently randomized controlled trials about perioperative goal-directed fluid replacement of children undergoing (neuro)-surgery with major blood loss are needed.
format	article
author	Martin A. Schick Jonas Pippir Manuel F. Struck Jürgen Brugger Winfried Neuhaus Christian Wunder
author_facet	Martin A. Schick Jonas Pippir Manuel F. Struck Jürgen Brugger Winfried Neuhaus Christian Wunder
author_sort	Martin A. Schick
title	Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
title_short	Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
title_full	Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
title_fullStr	Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
title_full_unstemmed	Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
title_sort	comparison of hydroxyethylstarch (hes 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: a retrospective, single center study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1accb5b2591649c3998785538fb77001
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Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study

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