Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis

Glucocorticoids (GCs), a class of corticosteroids produced by the adrenal cortex in response to stress, exert obesity-promoting effects. Although adaptive thermogenesis has been considered an effective approach to counteract obesity, whether GCs play a role in regulating cold stress-induced thermoge...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liping Luo, Lu Wang, Yan Luo, Estevan Romero, Xin Yang, Meilian Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glucocorticoid adiponectin WAT beige adipocytes PPARγ Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1acd0aa079b94f339f1a1d257b4cd35c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1acd0aa079b94f339f1a1d257b4cd35c
record_format	dspace
spelling	oai:doaj.org-article:1acd0aa079b94f339f1a1d257b4cd35c2021-11-25T16:52:04ZGlucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis10.3390/biom111115732218-273Xhttps://doaj.org/article/1acd0aa079b94f339f1a1d257b4cd35c2021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1573https://doaj.org/toc/2218-273XGlucocorticoids (GCs), a class of corticosteroids produced by the adrenal cortex in response to stress, exert obesity-promoting effects. Although adaptive thermogenesis has been considered an effective approach to counteract obesity, whether GCs play a role in regulating cold stress-induced thermogenesis remains incompletely understood. Here, we show that the circulating levels of stress hormone corticosterone (GC in rodents) were significantly elevated, whereas the levels of adiponectin, an adipokine that was linked to cold-induced adaptive thermogenesis, were decreased 48 h post cold exposure. The administration of a glucocorticoid hydrocortisone downregulated adiponectin protein and mRNA levels in both WAT and white adipocytes, and upregulated thermogenic gene expression in inguinal fat. In contrast, mifepristone, a glucocorticoid receptor antagonist, enhanced adiponectin expression and suppressed energy expenditure in vivo. Mechanistically, hydrocortisone suppressed adiponectin expression by antagonizing PPARγ in differentiated 3T3-L1 adipocytes. Ultimately, adiponectin deficiency restored mifepristone-decreased oxygen consumption and suppressed the expression of thermogenic genes in inguinal fat. Taken together, our study reveals that the GCs/adiponectin axis is a key regulator of beige fat thermogenesis in response to acute cold stress.Liping LuoLu WangYan LuoEstevan RomeroXin YangMeilian LiuMDPI AGarticleglucocorticoidadiponectinWATbeige adipocytesPPARγMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1573, p 1573 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glucocorticoid adiponectin WAT beige adipocytes PPARγ Microbiology QR1-502
spellingShingle	glucocorticoid adiponectin WAT beige adipocytes PPARγ Microbiology QR1-502 Liping Luo Lu Wang Yan Luo Estevan Romero Xin Yang Meilian Liu Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis
description	Glucocorticoids (GCs), a class of corticosteroids produced by the adrenal cortex in response to stress, exert obesity-promoting effects. Although adaptive thermogenesis has been considered an effective approach to counteract obesity, whether GCs play a role in regulating cold stress-induced thermogenesis remains incompletely understood. Here, we show that the circulating levels of stress hormone corticosterone (GC in rodents) were significantly elevated, whereas the levels of adiponectin, an adipokine that was linked to cold-induced adaptive thermogenesis, were decreased 48 h post cold exposure. The administration of a glucocorticoid hydrocortisone downregulated adiponectin protein and mRNA levels in both WAT and white adipocytes, and upregulated thermogenic gene expression in inguinal fat. In contrast, mifepristone, a glucocorticoid receptor antagonist, enhanced adiponectin expression and suppressed energy expenditure in vivo. Mechanistically, hydrocortisone suppressed adiponectin expression by antagonizing PPARγ in differentiated 3T3-L1 adipocytes. Ultimately, adiponectin deficiency restored mifepristone-decreased oxygen consumption and suppressed the expression of thermogenic genes in inguinal fat. Taken together, our study reveals that the GCs/adiponectin axis is a key regulator of beige fat thermogenesis in response to acute cold stress.
format	article
author	Liping Luo Lu Wang Yan Luo Estevan Romero Xin Yang Meilian Liu
author_facet	Liping Luo Lu Wang Yan Luo Estevan Romero Xin Yang Meilian Liu
author_sort	Liping Luo
title	Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis
title_short	Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis
title_full	Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis
title_fullStr	Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis
title_full_unstemmed	Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis
title_sort	glucocorticoid/adiponectin axis mediates full activation of cold-induced beige fat thermogenesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1acd0aa079b94f339f1a1d257b4cd35c
work_keys_str_mv	AT lipingluo glucocorticoidadiponectinaxismediatesfullactivationofcoldinducedbeigefatthermogenesis AT luwang glucocorticoidadiponectinaxismediatesfullactivationofcoldinducedbeigefatthermogenesis AT yanluo glucocorticoidadiponectinaxismediatesfullactivationofcoldinducedbeigefatthermogenesis AT estevanromero glucocorticoidadiponectinaxismediatesfullactivationofcoldinducedbeigefatthermogenesis AT xinyang glucocorticoidadiponectinaxismediatesfullactivationofcoldinducedbeigefatthermogenesis AT meilianliu glucocorticoidadiponectinaxismediatesfullactivationofcoldinducedbeigefatthermogenesis
_version_	1718412879976202240

Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis

Ejemplares similares