Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membr...

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Autores principales:	Sicai Zhang, Ronnie P.-A. Berntsson, William H. Tepp, Liang Tao, Eric A. Johnson, Pål Stenmark, Min Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ace838b4bf145588cda2cd87b10cd11
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spelling	oai:doaj.org-article:1ace838b4bf145588cda2cd87b10cd112021-12-02T15:38:45ZStructural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC10.1038/s41467-017-01534-z2041-1723https://doaj.org/article/1ace838b4bf145588cda2cd87b10cd112017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01534-zhttps://doaj.org/toc/2041-1723Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membranes.Sicai ZhangRonnie P.-A. BerntssonWilliam H. TeppLiang TaoEric A. JohnsonPål StenmarkMin DongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sicai Zhang Ronnie P.-A. Berntsson William H. Tepp Liang Tao Eric A. Johnson Pål Stenmark Min Dong Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
description	Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membranes.
format	article
author	Sicai Zhang Ronnie P.-A. Berntsson William H. Tepp Liang Tao Eric A. Johnson Pål Stenmark Min Dong
author_facet	Sicai Zhang Ronnie P.-A. Berntsson William H. Tepp Liang Tao Eric A. Johnson Pål Stenmark Min Dong
author_sort	Sicai Zhang
title	Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
title_short	Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
title_full	Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
title_fullStr	Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
title_full_unstemmed	Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
title_sort	structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin dc
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ace838b4bf145588cda2cd87b10cd11
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Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

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