Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membr...
Guardado en:
Autores principales: | Sicai Zhang, Ronnie P.-A. Berntsson, William H. Tepp, Liang Tao, Eric A. Johnson, Pål Stenmark, Min Dong |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/1ace838b4bf145588cda2cd87b10cd11 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Identification and characterization of a novel botulinum neurotoxin
por: Sicai Zhang, et al.
Publicado: (2017) -
Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
por: Liang Tao, et al.
Publicado: (2017) -
Isolation and Characterization of the Novel Botulinum Neurotoxin A Subtype 6
por: Molly S. Moritz, et al.
Publicado: (2018) -
On Botulinum Neurotoxin Variability
por: Cesare Montecucco, et al.
Publicado: (2015) -
Neurologic uses of botulinum neurotoxin type A
por: John P Ney, et al.
Publicado: (2007)