Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.

The antigens of the Duffy blood group system (DARC) act as a receptor for the interleukin IL-8. IL-8 plays an important role in the pathogenesis of chronic periodontitis due to its chemotactic properties on neutrophils. The aim of this study was to investigate a possible association of Duffy blood g...

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Autores principales:	Emília Ângela Sippert, Cléverson de Oliveira e Silva, Jeane Eliete Laguila Visentainer, Ana Maria Sell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ad0b3c26db0435e96a7118839397607
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spelling	oai:doaj.org-article:1ad0b3c26db0435e96a71188393976072021-11-18T08:40:22ZAssociation of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.1932-620310.1371/journal.pone.0083286https://doaj.org/article/1ad0b3c26db0435e96a71188393976072013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386171/?tool=EBIhttps://doaj.org/toc/1932-6203The antigens of the Duffy blood group system (DARC) act as a receptor for the interleukin IL-8. IL-8 plays an important role in the pathogenesis of chronic periodontitis due to its chemotactic properties on neutrophils. The aim of this study was to investigate a possible association of Duffy blood group gene polymorphisms with the -353T>A, -845T>C and -738T>A SNPs of the IL8 gene in chronic periodontitis. One hundred and twenty-four individuals with chronic periodontitis and 187 controls were enrolled. DNA was extracted using the salting-out method. The Duffy genotypes and IL8 gene promoter polymorphisms were investigated by PCR-RFLP. Statistical analyses were conducted using the Chi square test with Yates correction or Fisher's Exact Test, and the possibility of associations were evaluated by odds ratio with a 95% confidence interval. When analyzed separately, for the Duffy blood group system, differences in the genotype and allele frequencies were not observed between all the groups analyzed; and, in nonsmokers, the -845C allele (3.6% vs. 0.4%), -845TC genotype (7.3% vs. 0.7%) and the CTA haplotype (3.6% vs. 0.4%) were positively associated with chronic periodontitis. For the first time to our knowledge, the polymorphisms of erythroid DARC plus IL8 -353T>A SNPs were associated with chronic periodontitis in Brazilian individuals. In Afro-Brazilians patients, the FY*02N.01 with IL8 -353A SNP was associated with protection to chronic periodontitis.Emília Ângela SippertCléverson de Oliveira e SilvaJeane Eliete Laguila VisentainerAna Maria SellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83286 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emília Ângela Sippert Cléverson de Oliveira e Silva Jeane Eliete Laguila Visentainer Ana Maria Sell Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.
description	The antigens of the Duffy blood group system (DARC) act as a receptor for the interleukin IL-8. IL-8 plays an important role in the pathogenesis of chronic periodontitis due to its chemotactic properties on neutrophils. The aim of this study was to investigate a possible association of Duffy blood group gene polymorphisms with the -353T>A, -845T>C and -738T>A SNPs of the IL8 gene in chronic periodontitis. One hundred and twenty-four individuals with chronic periodontitis and 187 controls were enrolled. DNA was extracted using the salting-out method. The Duffy genotypes and IL8 gene promoter polymorphisms were investigated by PCR-RFLP. Statistical analyses were conducted using the Chi square test with Yates correction or Fisher's Exact Test, and the possibility of associations were evaluated by odds ratio with a 95% confidence interval. When analyzed separately, for the Duffy blood group system, differences in the genotype and allele frequencies were not observed between all the groups analyzed; and, in nonsmokers, the -845C allele (3.6% vs. 0.4%), -845TC genotype (7.3% vs. 0.7%) and the CTA haplotype (3.6% vs. 0.4%) were positively associated with chronic periodontitis. For the first time to our knowledge, the polymorphisms of erythroid DARC plus IL8 -353T>A SNPs were associated with chronic periodontitis in Brazilian individuals. In Afro-Brazilians patients, the FY*02N.01 with IL8 -353A SNP was associated with protection to chronic periodontitis.
format	article
author	Emília Ângela Sippert Cléverson de Oliveira e Silva Jeane Eliete Laguila Visentainer Ana Maria Sell
author_facet	Emília Ângela Sippert Cléverson de Oliveira e Silva Jeane Eliete Laguila Visentainer Ana Maria Sell
author_sort	Emília Ângela Sippert
title	Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.
title_short	Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.
title_full	Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.
title_fullStr	Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.
title_full_unstemmed	Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.
title_sort	association of duffy blood group gene polymorphisms with il8 gene in chronic periodontitis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1ad0b3c26db0435e96a7118839397607
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_version_	1718421431021207552

Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis.

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