Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.

<h4>Objectives</h4>We sought to systematically review the evidence supporting the role of drug coated balloons (DCBs) in the treatment of coronary bifurcation lesions.<h4>Background</h4>DCBs are emerging as an attractive alternative treatment strategy for treating coronary bi...

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Autores principales:	Natasha H Corballis, Sophie Paddock, Tharusha Gunawardena, Ioannis Merinopoulos, Vassilios S Vassiliou, Simon C Eccleshall
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ad12e49c9cb40ebb8acc6a01b0fe089
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spelling	oai:doaj.org-article:1ad12e49c9cb40ebb8acc6a01b0fe0892021-12-02T20:05:09ZDrug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.1932-620310.1371/journal.pone.0251986https://doaj.org/article/1ad12e49c9cb40ebb8acc6a01b0fe0892021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251986https://doaj.org/toc/1932-6203<h4>Objectives</h4>We sought to systematically review the evidence supporting the role of drug coated balloons (DCBs) in the treatment of coronary bifurcation lesions.<h4>Background</h4>DCBs are emerging as an attractive alternative treatment strategy for treating coronary bifurcations due to simplifying the approach and reducing rates of stent related complications. We systematically reviewed the evidence for DCB use in coronary bifurcations and conducted a focused meta-analysis on late lumen loss in the side branch comparing DCB and plain old balloon angioplasty (POBA).<h4>Methods</h4>This study was conducted in line with the PRISMA statement. All studies (including both RCTs and observational studies, excluding case reports) using DCB as part of a bifurcation strategy were included in this review. A literature search identified a total of ten studies for inclusion. A focused meta-analysis was undertaken for the use of DCB in side-branch compared with POBA. Mean late lumen loss was used with a random effects model due to heterogeneity.<h4>Results</h4>DCB was found to be superior to POBA for side branch treatment in bifurcations (p = 0.01). There are four studies that investigated the use of DCB for main branch treatment in a bifurcation, with evidence supporting its safety in main branches of bifurcation lesions, while prospective observational studies have demonstrated favourable target lesion revascularisation rates.<h4>Conclusion</h4>Although there is a lack of robust RCTs comparing DCBs with current generation DES, DCBs appear safe in main branch bifurcation lesions with improved side branch late lumen loss when compared with DES or POBA.Natasha H CorballisSophie PaddockTharusha GunawardenaIoannis MerinopoulosVassilios S VassiliouSimon C EccleshallPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0251986 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natasha H Corballis Sophie Paddock Tharusha Gunawardena Ioannis Merinopoulos Vassilios S Vassiliou Simon C Eccleshall Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.
description	<h4>Objectives</h4>We sought to systematically review the evidence supporting the role of drug coated balloons (DCBs) in the treatment of coronary bifurcation lesions.<h4>Background</h4>DCBs are emerging as an attractive alternative treatment strategy for treating coronary bifurcations due to simplifying the approach and reducing rates of stent related complications. We systematically reviewed the evidence for DCB use in coronary bifurcations and conducted a focused meta-analysis on late lumen loss in the side branch comparing DCB and plain old balloon angioplasty (POBA).<h4>Methods</h4>This study was conducted in line with the PRISMA statement. All studies (including both RCTs and observational studies, excluding case reports) using DCB as part of a bifurcation strategy were included in this review. A literature search identified a total of ten studies for inclusion. A focused meta-analysis was undertaken for the use of DCB in side-branch compared with POBA. Mean late lumen loss was used with a random effects model due to heterogeneity.<h4>Results</h4>DCB was found to be superior to POBA for side branch treatment in bifurcations (p = 0.01). There are four studies that investigated the use of DCB for main branch treatment in a bifurcation, with evidence supporting its safety in main branches of bifurcation lesions, while prospective observational studies have demonstrated favourable target lesion revascularisation rates.<h4>Conclusion</h4>Although there is a lack of robust RCTs comparing DCBs with current generation DES, DCBs appear safe in main branch bifurcation lesions with improved side branch late lumen loss when compared with DES or POBA.
format	article
author	Natasha H Corballis Sophie Paddock Tharusha Gunawardena Ioannis Merinopoulos Vassilios S Vassiliou Simon C Eccleshall
author_facet	Natasha H Corballis Sophie Paddock Tharusha Gunawardena Ioannis Merinopoulos Vassilios S Vassiliou Simon C Eccleshall
author_sort	Natasha H Corballis
title	Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.
title_short	Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.
title_full	Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.
title_fullStr	Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.
title_full_unstemmed	Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.
title_sort	drug coated balloons for coronary artery bifurcation lesions: a systematic review and focused meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1ad12e49c9cb40ebb8acc6a01b0fe089
work_keys_str_mv	AT natashahcorballis drugcoatedballoonsforcoronaryarterybifurcationlesionsasystematicreviewandfocusedmetaanalysis AT sophiepaddock drugcoatedballoonsforcoronaryarterybifurcationlesionsasystematicreviewandfocusedmetaanalysis AT tharushagunawardena drugcoatedballoonsforcoronaryarterybifurcationlesionsasystematicreviewandfocusedmetaanalysis AT ioannismerinopoulos drugcoatedballoonsforcoronaryarterybifurcationlesionsasystematicreviewandfocusedmetaanalysis AT vassiliossvassiliou drugcoatedballoonsforcoronaryarterybifurcationlesionsasystematicreviewandfocusedmetaanalysis AT simonceccleshall drugcoatedballoonsforcoronaryarterybifurcationlesionsasystematicreviewandfocusedmetaanalysis
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Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.

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