Conserved long-range base pairings are associated with pre-mRNA processing of human genes

Functional RNA secondary structure is important for the pre-mRNA processing including splicing, cleavage and polyadenylation, and RNA editing. Here the authors present a catalog of conserved long-range RNA structures in the human transcriptome by defining pairs of conserved complementary regions (PC...

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Autores principales:	Svetlana Kalmykova, Marina Kalinina, Stepan Denisov, Alexey Mironov, Dmitry Skvortsov, Roderic Guigó, Dmitri Pervouchine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ad52ce1c1dc4d7a87afa84114c6aa3c
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spelling	oai:doaj.org-article:1ad52ce1c1dc4d7a87afa84114c6aa3c2021-12-02T18:02:47ZConserved long-range base pairings are associated with pre-mRNA processing of human genes10.1038/s41467-021-22549-72041-1723https://doaj.org/article/1ad52ce1c1dc4d7a87afa84114c6aa3c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22549-7https://doaj.org/toc/2041-1723Functional RNA secondary structure is important for the pre-mRNA processing including splicing, cleavage and polyadenylation, and RNA editing. Here the authors present a catalog of conserved long-range RNA structures in the human transcriptome by defining pairs of conserved complementary regions (PCCR) in pre-aligned evolutionarily conserved regions.Svetlana KalmykovaMarina KalininaStepan DenisovAlexey MironovDmitry SkvortsovRoderic GuigóDmitri PervouchineNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Svetlana Kalmykova Marina Kalinina Stepan Denisov Alexey Mironov Dmitry Skvortsov Roderic Guigó Dmitri Pervouchine Conserved long-range base pairings are associated with pre-mRNA processing of human genes
description	Functional RNA secondary structure is important for the pre-mRNA processing including splicing, cleavage and polyadenylation, and RNA editing. Here the authors present a catalog of conserved long-range RNA structures in the human transcriptome by defining pairs of conserved complementary regions (PCCR) in pre-aligned evolutionarily conserved regions.
format	article
author	Svetlana Kalmykova Marina Kalinina Stepan Denisov Alexey Mironov Dmitry Skvortsov Roderic Guigó Dmitri Pervouchine
author_facet	Svetlana Kalmykova Marina Kalinina Stepan Denisov Alexey Mironov Dmitry Skvortsov Roderic Guigó Dmitri Pervouchine
author_sort	Svetlana Kalmykova
title	Conserved long-range base pairings are associated with pre-mRNA processing of human genes
title_short	Conserved long-range base pairings are associated with pre-mRNA processing of human genes
title_full	Conserved long-range base pairings are associated with pre-mRNA processing of human genes
title_fullStr	Conserved long-range base pairings are associated with pre-mRNA processing of human genes
title_full_unstemmed	Conserved long-range base pairings are associated with pre-mRNA processing of human genes
title_sort	conserved long-range base pairings are associated with pre-mrna processing of human genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ad52ce1c1dc4d7a87afa84114c6aa3c
work_keys_str_mv	AT svetlanakalmykova conservedlongrangebasepairingsareassociatedwithpremrnaprocessingofhumangenes AT marinakalinina conservedlongrangebasepairingsareassociatedwithpremrnaprocessingofhumangenes AT stepandenisov conservedlongrangebasepairingsareassociatedwithpremrnaprocessingofhumangenes AT alexeymironov conservedlongrangebasepairingsareassociatedwithpremrnaprocessingofhumangenes AT dmitryskvortsov conservedlongrangebasepairingsareassociatedwithpremrnaprocessingofhumangenes AT rodericguigo conservedlongrangebasepairingsareassociatedwithpremrnaprocessingofhumangenes AT dmitripervouchine conservedlongrangebasepairingsareassociatedwithpremrnaprocessingofhumangenes
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Conserved long-range base pairings are associated with pre-mRNA processing of human genes

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