Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach

Upon transition to stationary phase or upon stress, bacteria limit protein synthesis through small inhibitory proteins that bind the ribosome. Here the authors decipher the interaction mode of the bacterial ribosome silencing factor (RsfS) at atomic details to provide an in depth view of how it shut...

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Autores principales:	Iskander Khusainov, Bulat Fatkhullin, Simone Pellegrino, Aydar Bikmullin, Wen-ti Liu, Azat Gabdulkhakov, Amr Al Shebel, Alexander Golubev, Denis Zeyer, Natalie Trachtmann, Georg A. Sprenger, Shamil Validov, Konstantin Usachev, Gulnara Yusupova, Marat Yusupov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ad738db839640ba9241f8a79ce45330
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spelling	oai:doaj.org-article:1ad738db839640ba9241f8a79ce453302021-12-02T14:40:50ZMechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach10.1038/s41467-020-15517-02041-1723https://doaj.org/article/1ad738db839640ba9241f8a79ce453302020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15517-0https://doaj.org/toc/2041-1723Upon transition to stationary phase or upon stress, bacteria limit protein synthesis through small inhibitory proteins that bind the ribosome. Here the authors decipher the interaction mode of the bacterial ribosome silencing factor (RsfS) at atomic details to provide an in depth view of how it shutdowns ribosomes.Iskander KhusainovBulat FatkhullinSimone PellegrinoAydar BikmullinWen-ti LiuAzat GabdulkhakovAmr Al ShebelAlexander GolubevDenis ZeyerNatalie TrachtmannGeorg A. SprengerShamil ValidovKonstantin UsachevGulnara YusupovaMarat YusupovNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iskander Khusainov Bulat Fatkhullin Simone Pellegrino Aydar Bikmullin Wen-ti Liu Azat Gabdulkhakov Amr Al Shebel Alexander Golubev Denis Zeyer Natalie Trachtmann Georg A. Sprenger Shamil Validov Konstantin Usachev Gulnara Yusupova Marat Yusupov Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
description	Upon transition to stationary phase or upon stress, bacteria limit protein synthesis through small inhibitory proteins that bind the ribosome. Here the authors decipher the interaction mode of the bacterial ribosome silencing factor (RsfS) at atomic details to provide an in depth view of how it shutdowns ribosomes.
format	article
author	Iskander Khusainov Bulat Fatkhullin Simone Pellegrino Aydar Bikmullin Wen-ti Liu Azat Gabdulkhakov Amr Al Shebel Alexander Golubev Denis Zeyer Natalie Trachtmann Georg A. Sprenger Shamil Validov Konstantin Usachev Gulnara Yusupova Marat Yusupov
author_facet	Iskander Khusainov Bulat Fatkhullin Simone Pellegrino Aydar Bikmullin Wen-ti Liu Azat Gabdulkhakov Amr Al Shebel Alexander Golubev Denis Zeyer Natalie Trachtmann Georg A. Sprenger Shamil Validov Konstantin Usachev Gulnara Yusupova Marat Yusupov
author_sort	Iskander Khusainov
title	Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
title_short	Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
title_full	Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
title_fullStr	Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
title_full_unstemmed	Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
title_sort	mechanism of ribosome shutdown by rsfs in staphylococcus aureus revealed by integrative structural biology approach
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1ad738db839640ba9241f8a79ce45330
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Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach

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