Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe

Current sensors for intracellular H2O2 are not sensitive enough to detect all biologically relevant H2O2 fluctuations. Here the authors develop a peroxiredoxin-2-based FRET probe that is sensitive enough to measure changes in H2O2 concentration in response to the cancer therapeutic piperlongumine.

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Detalles Bibliográficos
Autores principales:	Troy F. Langford, Beijing K. Huang, Joseph B. Lim, Sun Jin Moon, Hadley D. Sikes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ada60e3af9c4daab6f468fb7f0175c1
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id	oai:doaj.org-article:1ada60e3af9c4daab6f468fb7f0175c1
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spelling	oai:doaj.org-article:1ada60e3af9c4daab6f468fb7f0175c12021-12-02T17:31:16ZMonitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe10.1038/s41467-018-05557-y2041-1723https://doaj.org/article/1ada60e3af9c4daab6f468fb7f0175c12018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05557-yhttps://doaj.org/toc/2041-1723Current sensors for intracellular H2O2 are not sensitive enough to detect all biologically relevant H2O2 fluctuations. Here the authors develop a peroxiredoxin-2-based FRET probe that is sensitive enough to measure changes in H2O2 concentration in response to the cancer therapeutic piperlongumine.Troy F. LangfordBeijing K. HuangJoseph B. LimSun Jin MoonHadley D. SikesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Troy F. Langford Beijing K. Huang Joseph B. Lim Sun Jin Moon Hadley D. Sikes Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe
description	Current sensors for intracellular H2O2 are not sensitive enough to detect all biologically relevant H2O2 fluctuations. Here the authors develop a peroxiredoxin-2-based FRET probe that is sensitive enough to measure changes in H2O2 concentration in response to the cancer therapeutic piperlongumine.
format	article
author	Troy F. Langford Beijing K. Huang Joseph B. Lim Sun Jin Moon Hadley D. Sikes
author_facet	Troy F. Langford Beijing K. Huang Joseph B. Lim Sun Jin Moon Hadley D. Sikes
author_sort	Troy F. Langford
title	Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe
title_short	Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe
title_full	Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe
title_fullStr	Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe
title_full_unstemmed	Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe
title_sort	monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1ada60e3af9c4daab6f468fb7f0175c1
work_keys_str_mv	AT troyflangford monitoringtheactionofredoxdirectedcancertherapeuticsusingahumanperoxiredoxin2basedprobe AT beijingkhuang monitoringtheactionofredoxdirectedcancertherapeuticsusingahumanperoxiredoxin2basedprobe AT josephblim monitoringtheactionofredoxdirectedcancertherapeuticsusingahumanperoxiredoxin2basedprobe AT sunjinmoon monitoringtheactionofredoxdirectedcancertherapeuticsusingahumanperoxiredoxin2basedprobe AT hadleydsikes monitoringtheactionofredoxdirectedcancertherapeuticsusingahumanperoxiredoxin2basedprobe
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Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe

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