A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex

Biochemistry combined with biophysical measurements and mathematical modeling offer insight into the mechanism by which the cotranslational chaperone, nascent polypeptide-associated complex (NAC), modulates substrate selection by signal recognition particle (SRP) and reduces aberrant, nonspecific ta...

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Autores principales:	Hao-Hsuan Hsieh, Jae Ho Lee, Sowmya Chandrasekar, Shu-ou Shan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1adc0df7a6714d4c96bfb07681a11801
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spelling	oai:doaj.org-article:1adc0df7a6714d4c96bfb07681a118012021-12-02T16:50:02ZA ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex10.1038/s41467-020-19548-52041-1723https://doaj.org/article/1adc0df7a6714d4c96bfb07681a118012020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19548-5https://doaj.org/toc/2041-1723Biochemistry combined with biophysical measurements and mathematical modeling offer insight into the mechanism by which the cotranslational chaperone, nascent polypeptide-associated complex (NAC), modulates substrate selection by signal recognition particle (SRP) and reduces aberrant, nonspecific targeting of ribosomes to the ER.Hao-Hsuan HsiehJae Ho LeeSowmya ChandrasekarShu-ou ShanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao-Hsuan Hsieh Jae Ho Lee Sowmya Chandrasekar Shu-ou Shan A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
description	Biochemistry combined with biophysical measurements and mathematical modeling offer insight into the mechanism by which the cotranslational chaperone, nascent polypeptide-associated complex (NAC), modulates substrate selection by signal recognition particle (SRP) and reduces aberrant, nonspecific targeting of ribosomes to the ER.
format	article
author	Hao-Hsuan Hsieh Jae Ho Lee Sowmya Chandrasekar Shu-ou Shan
author_facet	Hao-Hsuan Hsieh Jae Ho Lee Sowmya Chandrasekar Shu-ou Shan
author_sort	Hao-Hsuan Hsieh
title	A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
title_short	A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
title_full	A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
title_fullStr	A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
title_full_unstemmed	A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
title_sort	ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1adc0df7a6714d4c96bfb07681a11801
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A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex

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