A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex

Biochemistry combined with biophysical measurements and mathematical modeling offer insight into the mechanism by which the cotranslational chaperone, nascent polypeptide-associated complex (NAC), modulates substrate selection by signal recognition particle (SRP) and reduces aberrant, nonspecific ta...

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Autores principales: Hao-Hsuan Hsieh, Jae Ho Lee, Sowmya Chandrasekar, Shu-ou Shan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1adc0df7a6714d4c96bfb07681a11801
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