A Group A Streptococcus ADP-Ribosyltransferase Toxin Stimulates a Protective Interleukin 1β-Dependent Macrophage Immune Response

A Group A Streptococcus ADP-Ribosyltransferase Toxin Stimulates a Protective Interleukin 1β-Dependent Macrophage Immune Response

ABSTRACT The M1T1 clone of group A Streptococcus (GAS) is associated with severe invasive infections, including necrotizing fasciitis and septicemia. During invasive M1T1 GAS disease, mutations in the covRS regulatory system led to upregulation of an ADP-ribosyltransferase, SpyA. Surprisingly, a GAS...

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Autores principales: Ann E. Lin, Federico C. Beasley, Nadia Keller, Andrew Hollands, Rodolfo Urbano, Emily R. Troemel, Hal M. Hoffman, Victor Nizet
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/1ae0b0c745294a0da11db658350bbcde
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