Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

Homeobox protein Mohwak (Mkx) is involved in tendon and ligament development. Here the authors show that Mkx in the outer annulus fibrosus of the intervertebral disc plays a role in maintenance of the IVD, showing that stem cells overexpressing Mkx enhance therapeutic IVD regeneration in mice.

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Autores principales:	Ryo Nakamichi, Yoshiaki Ito, Masafumi Inui, Naoko Onizuka, Tomohiro Kayama, Kensuke Kataoka, Hidetsugu Suzuki, Masaki Mori, Masayo Inagawa, Shizuko Ichinose, Martin K. Lotz, Daisuke Sakai, Koichi Masuda, Toshifumi Ozaki, Hiroshi Asahara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ae218da6e53457ca91ea8cbde500126
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spelling	oai:doaj.org-article:1ae218da6e53457ca91ea8cbde5001262021-12-02T17:32:53ZMohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs10.1038/ncomms125032041-1723https://doaj.org/article/1ae218da6e53457ca91ea8cbde5001262016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12503https://doaj.org/toc/2041-1723Homeobox protein Mohwak (Mkx) is involved in tendon and ligament development. Here the authors show that Mkx in the outer annulus fibrosus of the intervertebral disc plays a role in maintenance of the IVD, showing that stem cells overexpressing Mkx enhance therapeutic IVD regeneration in mice.Ryo NakamichiYoshiaki ItoMasafumi InuiNaoko OnizukaTomohiro KayamaKensuke KataokaHidetsugu SuzukiMasaki MoriMasayo InagawaShizuko IchinoseMartin K. LotzDaisuke SakaiKoichi MasudaToshifumi OzakiHiroshi AsaharaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryo Nakamichi Yoshiaki Ito Masafumi Inui Naoko Onizuka Tomohiro Kayama Kensuke Kataoka Hidetsugu Suzuki Masaki Mori Masayo Inagawa Shizuko Ichinose Martin K. Lotz Daisuke Sakai Koichi Masuda Toshifumi Ozaki Hiroshi Asahara Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
description	Homeobox protein Mohwak (Mkx) is involved in tendon and ligament development. Here the authors show that Mkx in the outer annulus fibrosus of the intervertebral disc plays a role in maintenance of the IVD, showing that stem cells overexpressing Mkx enhance therapeutic IVD regeneration in mice.
format	article
author	Ryo Nakamichi Yoshiaki Ito Masafumi Inui Naoko Onizuka Tomohiro Kayama Kensuke Kataoka Hidetsugu Suzuki Masaki Mori Masayo Inagawa Shizuko Ichinose Martin K. Lotz Daisuke Sakai Koichi Masuda Toshifumi Ozaki Hiroshi Asahara
author_facet	Ryo Nakamichi Yoshiaki Ito Masafumi Inui Naoko Onizuka Tomohiro Kayama Kensuke Kataoka Hidetsugu Suzuki Masaki Mori Masayo Inagawa Shizuko Ichinose Martin K. Lotz Daisuke Sakai Koichi Masuda Toshifumi Ozaki Hiroshi Asahara
author_sort	Ryo Nakamichi
title	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
title_short	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
title_full	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
title_fullStr	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
title_full_unstemmed	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
title_sort	mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1ae218da6e53457ca91ea8cbde500126
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Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

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