Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun

Abstract The Src-family tyrosine kinase Lck is an enzyme associated with the CD4 and CD8 co-receptors and promoting signaling through the T cell receptor (TCR) complex. The levels of Lck expression and activity change during the development and differentiation of T cells. Here we show that Lck expre...

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Autores principales:	Yury V. Shebzukhov, Silke Stanislawiak, Taisiya R. Bezhaeva, Sergei A. Nedospasov, Dmitry V. Kuprash
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ae3db244fd44027909211aba16d40a4
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spelling	oai:doaj.org-article:1ae3db244fd44027909211aba16d40a42021-12-02T15:05:17ZLow level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun10.1038/s41598-017-02553-y2045-2322https://doaj.org/article/1ae3db244fd44027909211aba16d40a42017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02553-yhttps://doaj.org/toc/2045-2322Abstract The Src-family tyrosine kinase Lck is an enzyme associated with the CD4 and CD8 co-receptors and promoting signaling through the T cell receptor (TCR) complex. The levels of Lck expression and activity change during the development and differentiation of T cells. Here we show that Lck expression is higher in Th1 cells as compared to Th2 cells. Ectopic overexpression of Lck in Th2 cells results in increased expression of CD4 co-receptor and enhanced S73 phosphorylation of transcription factor c-Jun. Our findings indicate that TCR-mediated signaling in Th2 cells may be directly attenuated by Lck protein expression level.Yury V. ShebzukhovSilke StanislawiakTaisiya R. BezhaevaSergei A. NedospasovDmitry V. KuprashNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yury V. Shebzukhov Silke Stanislawiak Taisiya R. Bezhaeva Sergei A. Nedospasov Dmitry V. Kuprash Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun
description	Abstract The Src-family tyrosine kinase Lck is an enzyme associated with the CD4 and CD8 co-receptors and promoting signaling through the T cell receptor (TCR) complex. The levels of Lck expression and activity change during the development and differentiation of T cells. Here we show that Lck expression is higher in Th1 cells as compared to Th2 cells. Ectopic overexpression of Lck in Th2 cells results in increased expression of CD4 co-receptor and enhanced S73 phosphorylation of transcription factor c-Jun. Our findings indicate that TCR-mediated signaling in Th2 cells may be directly attenuated by Lck protein expression level.
format	article
author	Yury V. Shebzukhov Silke Stanislawiak Taisiya R. Bezhaeva Sergei A. Nedospasov Dmitry V. Kuprash
author_facet	Yury V. Shebzukhov Silke Stanislawiak Taisiya R. Bezhaeva Sergei A. Nedospasov Dmitry V. Kuprash
author_sort	Yury V. Shebzukhov
title	Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun
title_short	Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun
title_full	Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun
title_fullStr	Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun
title_full_unstemmed	Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun
title_sort	low level of lck kinase in th2 cells limits expression of cd4 co-receptor and s73 phosphorylation of transcription factor c-jun
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ae3db244fd44027909211aba16d40a4
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Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun

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