P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

Systemic sepsis is a potentially life-threatening illness and immunocompromised individuals are especially vulnerable. Here, using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome in establishing a host response, and NLRP3 dysfunc...

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Autores principales:	Juan José Martínez-García, Helios Martínez-Banaclocha, Diego Angosto-Bazarra, Carlos de Torre-Minguela, Alberto Baroja-Mazo, Cristina Alarcón-Vila, Laura Martínez-Alarcón, Joaquín Amores-Iniesta, Fátima Martín-Sánchez, Giovanni A. Ercole, Carlos M. Martínez, Ada González-Lisorge, José Fernández-Pacheco, Piedad Martínez-Gil, Sahil Adriouch, Friedrich Koch-Nolte, Juan Luján, Francisco Acosta-Villegas, Pascual Parrilla, Carlos García-Palenciano, Pablo Pelegrin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ae90a92ab1d45b3b618703a201c9c3b
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spelling	oai:doaj.org-article:1ae90a92ab1d45b3b618703a201c9c3b2021-12-02T14:35:56ZP2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis10.1038/s41467-019-10626-x2041-1723https://doaj.org/article/1ae90a92ab1d45b3b618703a201c9c3b2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10626-xhttps://doaj.org/toc/2041-1723Systemic sepsis is a potentially life-threatening illness and immunocompromised individuals are especially vulnerable. Here, using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome in establishing a host response, and NLRP3 dysfunction is a common feature of sepsis mortality.Juan José Martínez-GarcíaHelios Martínez-BanaclochaDiego Angosto-BazarraCarlos de Torre-MinguelaAlberto Baroja-MazoCristina Alarcón-VilaLaura Martínez-AlarcónJoaquín Amores-IniestaFátima Martín-SánchezGiovanni A. ErcoleCarlos M. MartínezAda González-LisorgeJosé Fernández-PachecoPiedad Martínez-GilSahil AdriouchFriedrich Koch-NolteJuan LujánFrancisco Acosta-VillegasPascual ParrillaCarlos García-PalencianoPablo PelegrinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juan José Martínez-García Helios Martínez-Banaclocha Diego Angosto-Bazarra Carlos de Torre-Minguela Alberto Baroja-Mazo Cristina Alarcón-Vila Laura Martínez-Alarcón Joaquín Amores-Iniesta Fátima Martín-Sánchez Giovanni A. Ercole Carlos M. Martínez Ada González-Lisorge José Fernández-Pacheco Piedad Martínez-Gil Sahil Adriouch Friedrich Koch-Nolte Juan Luján Francisco Acosta-Villegas Pascual Parrilla Carlos García-Palenciano Pablo Pelegrin P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
description	Systemic sepsis is a potentially life-threatening illness and immunocompromised individuals are especially vulnerable. Here, using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome in establishing a host response, and NLRP3 dysfunction is a common feature of sepsis mortality.
format	article
author	Juan José Martínez-García Helios Martínez-Banaclocha Diego Angosto-Bazarra Carlos de Torre-Minguela Alberto Baroja-Mazo Cristina Alarcón-Vila Laura Martínez-Alarcón Joaquín Amores-Iniesta Fátima Martín-Sánchez Giovanni A. Ercole Carlos M. Martínez Ada González-Lisorge José Fernández-Pacheco Piedad Martínez-Gil Sahil Adriouch Friedrich Koch-Nolte Juan Luján Francisco Acosta-Villegas Pascual Parrilla Carlos García-Palenciano Pablo Pelegrin
author_facet	Juan José Martínez-García Helios Martínez-Banaclocha Diego Angosto-Bazarra Carlos de Torre-Minguela Alberto Baroja-Mazo Cristina Alarcón-Vila Laura Martínez-Alarcón Joaquín Amores-Iniesta Fátima Martín-Sánchez Giovanni A. Ercole Carlos M. Martínez Ada González-Lisorge José Fernández-Pacheco Piedad Martínez-Gil Sahil Adriouch Friedrich Koch-Nolte Juan Luján Francisco Acosta-Villegas Pascual Parrilla Carlos García-Palenciano Pablo Pelegrin
author_sort	Juan José Martínez-García
title	P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
title_short	P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
title_full	P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
title_fullStr	P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
title_full_unstemmed	P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
title_sort	p2x7 receptor induces mitochondrial failure in monocytes and compromises nlrp3 inflammasome activation during sepsis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1ae90a92ab1d45b3b618703a201c9c3b
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P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

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