Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

Oesophageal adenocarcinoma is often treated with chemotherapy before surgery. Here, the authors sequence cancer samples before and after chemotherapy and examine how the genome changes, focusing on changes in driver gene mutations and differential clonal evolution between good and poor responders.

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Autores principales:	John M. Findlay, Francesc Castro-Giner, Seiko Makino, Emily Rayner, Christiana Kartsonaki, William Cross, Michal Kovac, Danny Ulahannan, Claire Palles, Richard S. Gillies, Thomas P. MacGregor, David Church, Nicholas D. Maynard, Francesca Buffa, Jean-Baptiste Cazier, Trevor A. Graham, Lai-Mun Wang, Ricky A. Sharma, Mark Middleton, Ian Tomlinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1aea2f25e1f04ce696257305762bffaf
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spelling	oai:doaj.org-article:1aea2f25e1f04ce696257305762bffaf2021-12-02T15:34:32ZDifferential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy10.1038/ncomms111112041-1723https://doaj.org/article/1aea2f25e1f04ce696257305762bffaf2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11111https://doaj.org/toc/2041-1723Oesophageal adenocarcinoma is often treated with chemotherapy before surgery. Here, the authors sequence cancer samples before and after chemotherapy and examine how the genome changes, focusing on changes in driver gene mutations and differential clonal evolution between good and poor responders.John M. FindlayFrancesc Castro-GinerSeiko MakinoEmily RaynerChristiana KartsonakiWilliam CrossMichal KovacDanny UlahannanClaire PallesRichard S. GilliesThomas P. MacGregorDavid ChurchNicholas D. MaynardFrancesca BuffaJean-Baptiste CazierTrevor A. GrahamLai-Mun WangRicky A. SharmaMark MiddletonIan TomlinsonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John M. Findlay Francesc Castro-Giner Seiko Makino Emily Rayner Christiana Kartsonaki William Cross Michal Kovac Danny Ulahannan Claire Palles Richard S. Gillies Thomas P. MacGregor David Church Nicholas D. Maynard Francesca Buffa Jean-Baptiste Cazier Trevor A. Graham Lai-Mun Wang Ricky A. Sharma Mark Middleton Ian Tomlinson Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
description	Oesophageal adenocarcinoma is often treated with chemotherapy before surgery. Here, the authors sequence cancer samples before and after chemotherapy and examine how the genome changes, focusing on changes in driver gene mutations and differential clonal evolution between good and poor responders.
format	article
author	John M. Findlay Francesc Castro-Giner Seiko Makino Emily Rayner Christiana Kartsonaki William Cross Michal Kovac Danny Ulahannan Claire Palles Richard S. Gillies Thomas P. MacGregor David Church Nicholas D. Maynard Francesca Buffa Jean-Baptiste Cazier Trevor A. Graham Lai-Mun Wang Ricky A. Sharma Mark Middleton Ian Tomlinson
author_facet	John M. Findlay Francesc Castro-Giner Seiko Makino Emily Rayner Christiana Kartsonaki William Cross Michal Kovac Danny Ulahannan Claire Palles Richard S. Gillies Thomas P. MacGregor David Church Nicholas D. Maynard Francesca Buffa Jean-Baptiste Cazier Trevor A. Graham Lai-Mun Wang Ricky A. Sharma Mark Middleton Ian Tomlinson
author_sort	John M. Findlay
title	Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
title_short	Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
title_full	Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
title_fullStr	Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
title_full_unstemmed	Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
title_sort	differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1aea2f25e1f04ce696257305762bffaf
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Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

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