Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal
Microorganisms mainly exist in the form of biofilm in nature. Biofilm can contaminate food and drinking water system, as well as cause chronic wound infections, thereby posing a potential threat to public health safety. In the last two decades, researchers have made efforts to investigate the geneti...
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Taylor & Francis Group
2021
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oai:doaj.org-article:1aebfe69125c46e996f55d84f1fdc4582021-11-04T15:51:54ZRegulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal2165-59792165-598710.1080/21655979.2021.1996747https://doaj.org/article/1aebfe69125c46e996f55d84f1fdc4582021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1996747https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Microorganisms mainly exist in the form of biofilm in nature. Biofilm can contaminate food and drinking water system, as well as cause chronic wound infections, thereby posing a potential threat to public health safety. In the last two decades, researchers have made efforts to investigate the genetic contributors control different stages of biofilm development (adherence, initiation, maturation, and dispersal). As an opportunistic pathogen, C. albicans causes severe superficial or systemic infections with high morbidity and mortality under conditions of immune dysfunction. It has been reported that 80% of C. albicans infections are directly or indirectly associated with biofilm formation on host or abiotic surfaces including indwelling medical devices, resulting in high morbidity and mortality. Significantly, the outcome of C. albicans biofilm development includes enhanced invasion, exacerbated inflammatory responses and intrinsic resistance to antimicrobial chemotherapy. Thus, this review aimed at providing a comprehensive overview of the regulatory network controls microbial biofilm development, with C. albicans as a representative, served as reference for therapeutic targets.Zhenbo XuKan WangDu MinThanapop SoteyomeHaifeng LanWei HongFang PengXin FuGongyong PengTengyi HuangJunyan LiuBirthe V. KjellerupTaylor & Francis Grouparticlemicrobial biofilmsheterogeneity, c. albicansregulatory networkBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
microbial biofilms heterogeneity, c. albicans regulatory network Biotechnology TP248.13-248.65 |
| spellingShingle |
microbial biofilms heterogeneity, c. albicans regulatory network Biotechnology TP248.13-248.65 Zhenbo Xu Kan Wang Du Min Thanapop Soteyome Haifeng Lan Wei Hong Fang Peng Xin Fu Gongyong Peng Tengyi Huang Junyan Liu Birthe V. Kjellerup Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal |
| description |
Microorganisms mainly exist in the form of biofilm in nature. Biofilm can contaminate food and drinking water system, as well as cause chronic wound infections, thereby posing a potential threat to public health safety. In the last two decades, researchers have made efforts to investigate the genetic contributors control different stages of biofilm development (adherence, initiation, maturation, and dispersal). As an opportunistic pathogen, C. albicans causes severe superficial or systemic infections with high morbidity and mortality under conditions of immune dysfunction. It has been reported that 80% of C. albicans infections are directly or indirectly associated with biofilm formation on host or abiotic surfaces including indwelling medical devices, resulting in high morbidity and mortality. Significantly, the outcome of C. albicans biofilm development includes enhanced invasion, exacerbated inflammatory responses and intrinsic resistance to antimicrobial chemotherapy. Thus, this review aimed at providing a comprehensive overview of the regulatory network controls microbial biofilm development, with C. albicans as a representative, served as reference for therapeutic targets. |
| format |
article |
| author |
Zhenbo Xu Kan Wang Du Min Thanapop Soteyome Haifeng Lan Wei Hong Fang Peng Xin Fu Gongyong Peng Tengyi Huang Junyan Liu Birthe V. Kjellerup |
| author_facet |
Zhenbo Xu Kan Wang Du Min Thanapop Soteyome Haifeng Lan Wei Hong Fang Peng Xin Fu Gongyong Peng Tengyi Huang Junyan Liu Birthe V. Kjellerup |
| author_sort |
Zhenbo Xu |
| title |
Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal |
| title_short |
Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal |
| title_full |
Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal |
| title_fullStr |
Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal |
| title_full_unstemmed |
Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal |
| title_sort |
regulatory network controls microbial biofilm development, with candida albicans as a representative: from adhesion to dispersal |
| publisher |
Taylor & Francis Group |
| publishDate |
2021 |
| url |
https://doaj.org/article/1aebfe69125c46e996f55d84f1fdc458 |
| work_keys_str_mv |
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1718444699309572096 |